| Company Name: |
Musechem |
| Tel: |
+1-800-259-7612 |
| Email: |
info@musechem.com |
Bithionol sulfoxide manufacturers
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| | Bithionol sulfoxide Basic information |
| Product Name: | Bithionol sulfoxide | | Synonyms: | 2,2’-sulfinylbis(4,6-dichloro-pheno;6,6’-sulfinylbis(2,4-dichlorophenol);bitins;disto-5-cogla;distobitin;sulphene;LABOTEST-BB LT00772303;2,4-dichloro-6-(3,5-dichloro-2-hydroxyphenyl)sulfinylphenol | | CAS: | 844-26-8 | | MF: | C12H6Cl4O3S | | MW: | 372.05 | | EINECS: | 212-679-2 | | Product Categories: | | | Mol File: | 844-26-8.mol |  |
| | Bithionol sulfoxide Chemical Properties |
| Melting point | 220 °C(Solv: methanol (67-56-1)) | | Boiling point | 532.7±50.0 °C(Predicted) | | density | 1.86±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 250 mg/mL (671.95 mM) | | form | Solid | | pka | 4.79±0.48(Predicted) | | color | White to off-white |
| WGK Germany | 3 | | RTECS | SM8800000 |
| | Bithionol sulfoxide Usage And Synthesis |
| Uses | Bithionol sulfoxide is an anti-infection agent for parasites. Bithionol sulfoxide has mutagenic activity. Bithionol sulfoxide can be used in the research of parasite infection, such as paragonimiasis, flukes andcestodes infection[1][2][5]. | | in vivo | Bithionol sulfoxide (oral administration) shows LD50 values of 1000-5000 mg/kg (mice) and about 5000 mg/kg (rats), and increased serum AST at high doses (5000-100 mg/kg)[3].
Bithionol sulfoxide (80 and 90 mg/kg, oral administration) is effective against natural rumen fluke infections in dairy cattle[4].
| Animal Model: | Dairy cattle[4] | | Dosage: | 60, 80 90 mg/kg | | Administration: | Oral administration | | Result: | Showed approximately 70% effective against rumen flukes infection at dosages of 80 and 90 mg/kg after one week post treatment. |
| | IC 50 | Schistosome | | References | [1] Florent RL, et al. In vitro toxicity of bithionol and bithionol sulphoxide to Neoparamoeba spp., the causative agent of amoebic gill disease (AGD). Dis Aquat Organ. 2010 Sep 17;91(3):257-62. DOI:10.3354/dao02269
[2] S P Yang, et al. Treatment of paragonimiasis with bithionol and bithionol sulfoxide. Dis Chest. 1967 Aug;52(2):220-32. DOI:10.1378/chest.52.2.220
[3] Lavri A, et al. Oral toxicity of bithionol sulfoxide in mice and rats. Zbornik Veterinarske Fakultete Univerza Ljubljana 1990 Vol.27 No.1 pp.33-39 ref.22.
[4] Chompoochan T, et al. The anthelmintic effects of bithionol sulfoxide against sheep experimentally infected with Fasciola gigantica[C]//ACIAR PROCEEDINGS. 1996: 189-194.
[5] D.Mourot, et al. Mutagenicity of bithionol sulfoxide and its metabolites in the Salmonella/mammalian microsome test. Mutation Research/Genetic Toxicology, 1987, 188(1): 53-55. |
| | Bithionol sulfoxide Preparation Products And Raw materials |
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