|
|
| Product Name: | DGAT-3 | | Synonyms: | DGAT-3;Cyclohexaneacetic acid, 4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]-, trans-;trans-4-[4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexaneacetic acid;Mino-7,7-diMethyl-2-((1r,4r)-4-(4-(4-a7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;trans-2-(4-(4-(4-aMino-7,7-diMethyl-7H-pyriMido[4,5-b][1,4]oxazin-6-yl)phenyl)cyclohexyl)acetic acid;2-((1,4-trans)-4-(4-(4-Amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)- phenyl)cyclohexyl)acetic acid;T-863;T 863;CS-120 | | CAS: | 701232-20-4 | | MF: | C22H26N4O3 | | MW: | 394.47 | | EINECS: | | | Product Categories: | | | Mol File: | 701232-20-4.mol |  |
| | DGAT-3 Chemical Properties |
| Boiling point | 616.6±55.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble15mg/mL (clear solution) | | pka | 4.72±0.10(Predicted) | | form | powder | | color | white to beige |
| | DGAT-3 Usage And Synthesis |
| Uses | T863 has been used as a diglyceride acyltransferase (DGAT1) inhibitor:
- to provide the opportunity to precisely control the DGAT inhibition
- to treat mouse embryonic fibroblasts (MEFs) to analyse lipid droplet biogenesis
- to specifically block neutral?lipid synthesis?and lipid droplet formation in HT-1080 cells
- to block lipid droplet (LD) formation
| | Biological Activity | diacylglycerol acyltransferase (dgat1) inhibitor | | Biochem/physiol Actions | T863 is an orally active, selective and potent DGAT1 (Acyl-CoA:diacylglycerol acyltransferase 1) inhibitor that interacts with the acyl-CoA binding site of DGAT1, and inhibits triacylglycerol synthesis in cells. T863 causes weight loss, reduction in serum and liver triglycerides, and improved insulin sensitivity in obese mice. |
| | DGAT-3 Preparation Products And Raw materials |
|