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Products Intro: Product Name:N,N-Dimethylaniline
Purity:99.9% Package:1KG;5USD
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Purity:99.00% Package:200KG Iron/Plastic drum Remarks:coating
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Products Intro: Product Name:N,N-Dimethylaniline
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Lastest Price from N,N-Dimethylaniline manufacturers

  • N,N-Dimethylaniline
  • US $8.00 / kg
  • 2019-05-13
  • CAS:121-69-7
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 10TON
  • N,N-Dimethylaniline
  • US $10.00 / KG
  • 2019-04-30
  • CAS:121-69-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 500tons/month
  • N,N-Dimethylaniline
  • US $1.00 / g
  • 2019-04-18
  • CAS:121-69-7
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 10000 Kilogram/Kilograms per Month
N,N-Dimethylaniline Basic information
Product Name:N,N-Dimethylaniline
Product Categories:Intermediates of Dyes and Pigments;Anilines, Aromatic Amines and Nitro Compounds;Organics;C-D, Puriss p.a. ACSNitrogen Compounds;Amines;Analytical Reagents for General Use;C8;Puriss p.a. ACS;C8Essential Chemicals;Nitrogen Compounds;Reagent Plus;Routine Reagents;organic chemical;Dyestuff Intermediates
Mol File:121-69-7.mol
N,N-Dimethylaniline Structure
N,N-Dimethylaniline Chemical Properties
Melting point 1.5-2.5 °C(lit.)
Boiling point 193-194 °C(lit.)
density 0.956 g/mL at 20 °C
vapor density 3 (vs air)
vapor pressure 2 mm Hg ( 25 °C)
refractive index n20/D 1.557(lit.)
Fp 158 °F
storage temp. 0-6°C
solubility 1.2g/l
pka5.15(at 25℃)
form Liquid
color Clear yellow
Relative polarity0.179
PH7.4 (1.2g/l, H2O, 20℃)
explosive limit1.2-7%(V)
Water Solubility 1 g/L (20 ºC)
Merck 14,3234
BRN 507140
Stability:Stable. Incompatible with strong oxidizing agents, strong acids, acid chlorides, acid anhydrides, chloroformates, halogens. Combustible.
CAS DataBase Reference121-69-7(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenamine, N,N-dimethyl-(121-69-7)
EPA Substance Registry SystemBenzenamine, N,N-dimethyl-(121-69-7)
Safety Information
Hazard Codes T,N
Risk Statements 61-20/21-51/53-40-23/24/25
Safety Statements 53-45-61-36/37-28A-28
RIDADR UN 2253 6.1/PG 2
WGK Germany 3
RTECS BX4725000
Autoignition Temperature370 °C DIN 51794
HS Code 2921 42 00
HazardClass 6.1
PackingGroup II
Hazardous Substances Data121-69-7(Hazardous Substances Data)
ToxicityLD50 orally in rats: 1.41 ml/kg (Smyth)
MSDS Information
ACROS English
SigmaAldrich English
ALFA English
N,N-Dimethylaniline Usage And Synthesis
Chemical Propertiesliquid
UsesSolvent; manufacture of vanillin, Michler's ketone, methyl violet and other dyes. As reagent for methanol, methyl furfural, H2O2, nitrate, alcohol, formaldehyde.
DefinitionChEBI: A tertiary amine that is aniline in which the amino hydrogens are replaced by two methyl groups.
Production MethodsN,N-Dimethylaniline is made by heating aniline, methyl alcohol and sulfuric acid under pressure, followed by hydrolysis of the sulfate formed with sodium hydroxide to the free base (Windholz et al 1983). United States production in 1975 was estimated at 4,600 metric tons (HSDB 1989).
General DescriptionA yellow to brown colored oily liquid with a fishlike odor. Less dense than water and insoluble in water. Flash point 150°F. Toxic by ingestion, inhalation, and skin absorption. Used to make dyes and as a solvent.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileExplosive decomposition occurred when finely divided benzoyl peroxide was allowed to react with N,N-Dimethylaniline by breaking an ampoule containing 0.5 grams of dimethylaniline in an autoclave, NFPA 491M, 1991. This result may be expected with other peroxides and various oxidants.
Health HazardTOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Health HazardClinical signs of intoxication with N,N-dimethylaniline in man are headaches, cyanosis, dizziness, labored breathing, paralysis and convulsions (HSDB 1989). It is absorbed through the skin to produce a dangerous methemoglobinemia (Gosselin 1984). Treatment is similar to that of aniline with the object of managing methemoglobinemia.
Fire HazardCombustible material: may burn but does not ignite readily. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
Industrial usesN,N-Dimethylaniline is used as chemical intermediate in the manufacturing of vanillin, Michler's ketone, and dyes such as Acid Red 2, Basic Green 4 and Basic Violet 1 (Northcott 1978). It is also used as a solvent and an activator for polyesters and as an alkylating agent (Beard and Noe 1981). It is used as an acid scavenger or accepter in the manufacture of beta-lactam antibiotics such as penicillin and cephalosporin (Nachtmann and Gstrein 1981).
Safety ProfileSuspected carcinogen with equivocal tumorigenic data. Human poison by ingestion. Moderately toxic by inhalation and skin contact. A skin irritant. Human systemic effects by ingestion: nausea or vomiting. Physiological action is similar to, but less toxic than, adne. A central nervous system depressant. Mutation data reported. Flammable liquid when exposed to heat, flame, or oxidizers. Explodes on contact with benzoyl peroxide or disopropyl peroxydicarbonate. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits htghly toxic fumes of adne and NOx. See also ANILINE.
MetabolismΝ,Ν-Dimethylaniline undergoes N-demethylation, N-oxidation, and ring hydroxylation in animals. Urinary metabolites produced by dogs and rabbits injected with this compound included 4-aminophenol, 4-dimethylaminophenol, 2-aminophenol and N-methylaniline (Williams 1959; Kiese and Renner 1974). N-oxidation, N-demethylation and ring hydroxylation of Ν,Ν-dimethylaniline was demonstrated in vitro using liver microsomal preparations from pigs, rats, rabbits, chickens, and guinea pigs (Fish et al 1955; Zeigler and Pettit 1964, 1966; Abou-Donia and Menzel 1968). N-oxidation was also demonstrated using whole homogenate of human liver (Zeigler and Gold 1971; Rane 1974). Evidence has been obtained with rabbit liver microsomes for two pathways for Ν,Ν-dimethylaniline N-oxidation (Hlavica and Kehl 1977). One pathway involves cytochrome P-450 while the second makes use of flavin-containing monooxygenase. N,N-Dimethylaniline was also metabolized to formaldehyde in the nasal and respiratory mucosa of Fischer 344 rats (McNulty et al 1983). Alveolar type II cells from rabbit and rat lungs catalyzed the N-oxidation of this compound (Devereux and Fouts 1974; Ohmiya and Mehendale 1981). The microsomal preparation from rat seminal vesicles when fortified with arachidonic acid catalyzed the dealkylation of N,Ndimethylaniline (Sivarajah et al 1982).
Purification MethodsPrimary and secondary amines (including aniline and monomethylaniline) can be removed by refluxing for 4-5hours with excess acetic anhydride, and then fractionally distilling. Crocker and Jones (J Chem Soc 1808 1959) used four volumes of acetic anhydride, then distilled off the greater part of it, and dissolved the residue in ice-cold dilute HCl. Non-basic materials were removed by ether extraction, then the dimethylaniline was liberated with ammonia, extracted with ether, dried, and distilled under reduced pressure. Metzler and Tobolsky (J Am Chem Soc 76 5178 1954) refluxed with only 10% (w/w) of acetic anhydride, then cooled and poured it into excess 20% HCl, which, after cooling, was extracted with diethyl ether. (The amine hydrochloride remains in the aqueous phase.) The HCl solution was cautiously made alkaline to phenolphthalein, and the amine layer was drawn off, dried over KOH and fractionally distilled under reduced pressure, under nitrogen. Suitable drying agents for dimethylaniline include NaOH, BaO, CaSO4, and CaH2. Other purification procedures include the formation of the picrate (m 163o from Me2CO or EtOH/H2O), prepared in *benzene solution and crystallised to constant melting point, then decomposed with warm 10% NaOH and extracted into ether: the extract was washed with water and distilled under reduced pressure. The oxalate salt has also been used for purification. The base has been fractionally crystallised by partial freezing and also from aqueous 80% EtOH then from absolute EtOH. It has been distilled from zinc dust, under nitrogen. [Beilstein 12 H 141, 12 I 151, 12 II 2, 12 III 245, 12 IV 243.]
Tag:N,N-Dimethylaniline(121-69-7) Related Product Information
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