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| 化学名: | M-35 | | 英語化学名: | M35 | | 别名: | M35;H-GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2;GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-PRO-PRO-GLY-PHE-SER-PRO-PHE-ARG-NH2;GALANIN (1-13)-BRADYKININ (2-9) AMIDE;GWTLNSAGYLLGPPPGFSPFR-NH2;GALANIN FRAGMENT (1-13)-BRADYKININ*FRAGMENT (2-9)AM;Galanin receptorligand M35;Galanin (1-13)-Bradykinin (2-9), amide, M35 | | CAS番号: | 142846-71-7 | | 分子式: | C107H153N27O26 | | 分子量: | 2233.52 | | EINECS: | | | カテゴリ情報: | Peptides for Cell Biology;Galanin receptor;Peptide;Galanins;Neuropeptides | | Mol File: | 142846-71-7.mol |  |
| 貯蔵温度 | −20°C | | 溶解性 | Soluble in DMSO | | 外見 | solid | | 色 | White to off-white | | シーケンス | Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-NH2 |
| 使用 | Galanin Receptor Ligand M35 is a high-affinity ligand and antagonist of galanin receptor (Kd=0.1 nM). Galanin Receptor Ligand M35 exerts a Ki values of 0.11 and 2.0 nM for human galanin receptor type 1 and 2, respectively[1][2]. | | in vivo | Galanin Receptor Ligand M35 (6 nM/10 μL; i.c.v.) improves the ability of the male Sprague-Dnwley rats to acquire the swim maze task[1]. | | 参考文献 | [1] Kask K, et al. Binding and agonist/antagonist actions of M35, galanin(1-13)-bradykinin(2-9)amide chimeric peptide, in Rin m 5F insulinoma cells. Regul Pept. 1995 Nov 10;59(3):341-8. DOI:10.1016/0167-0115(95)00089-t
[2] Webling KE, et al. Galanin receptors and ligands. Front Endocrinol (Lausanne). 2012 Dec 7;3:146. DOI:10.3389/fendo.2012.00146
[3] Ogren SO, et al. Evidence for a role of the neuropeptide galanin in spatial learning. Neuroscience. 1992 Nov;51(1):1-5. DOI:10.1016/0306-4522(92)90463-c |
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