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ChemicalBook Optimization Suppliers |
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| Rフレーズ | 52 | | Sフレーズ | 29/56 | | WGK Germany | 1 | | RTECS 番号 | UD3328750 | | HSコード | 29269095 | | 毒性 | LD50 orl-rat: >5 g/kg NTIS** OTS0556792 |
| | オクトクリレン Usage And Synthesis |
| 外観 | うすい黄色～くすんだ黄色～暗い緑色透明液体 | | 定義 | 本品は、次の化学式で表されるジフェニル化合物である。 | | 化粧品の成分用途 | 褪色防止剤、紫外線吸収剤.散乱剤 | | 効能 | 紫外線保護剤 | | 化学的特性 | Clear yellow viscous liquid with mild characteristic odor, Miscible in methanol, n-butanol, ethyl acetate, mineral oil, hexane, toluene. Immiscible in water. Octocrylene is an effective oil soluble liquid UV‐B filter. It has excellent dissolving properties for crystalline UV filters. | | 使用 | Octocrylene is an ingredient used in sunscreens for its ability to absorb UV rays, protecting the skin from sun damage. It is chemically related to cinnamates. It can be used to boost SPF and improve water resistance in a given formulation. Octocrylene is photostable and can improve the photostability of other sunscreens. It is expensive and can present difficulties in formulation. | | 主な応用 | octocrylene is a uVB sunscreen with strong water-resistant properties and a rather broad-band absorption range. It exhibits good photostability, and is being evaluated by many companies as an effective SPF booster and waterproofing enhancer. This is an expensive ingredient with an approved usage level of 7 to 10 percent in both the united States and the european union. Although gaining in popularity among formulators, its cost and usage level can limit use. In addition, some studies are indicating it may cause allergic reactions in skin with a history of photoallergy. | | 定義 | ChEBI: Octocrylene is a diarylmethane. It is an ester formed by the condensation of a diphenylcyanoacrylate with 2-ethylhexanol, used in sunscreens and cosmetics. | | 利点 | Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. Octocrylene protects the skin from the harmful effects of the sun and premature skin aging. It helps prevent the risk of skin cancer. This filter mainly absorbs UVB rays, and shorter UVA rays, which are responsible for aging but also for skin cancer. | | 一般的な説明 | Yellow viscous liquid. Insoluble in water. | | 空気と水の反応 | Insoluble in water. | | 反応プロフィール | Octocrilene is an ester derivative. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. | | 火災危険 | Flash point data for Octocrilene are not available. Octocrilene is probably combustible. | | 燃焼性と爆発性 | Non flammable | | 接触アレルゲン | Octocrylene is an anti-UVB filter used in cosmetics
that may induce photoallergic contact dermatitis. | | 副作用 | Some people are concerned about the body’s ability to absorb octocrylene, which can present in the blood, urine, and breast milk. It may promote the production of free radicals, which can damage DNA, potentially increasing the risk of melanoma. However, further research is necessary.
People with sensitive skin or skin conditions, such as eczema, may prefer to avoid products containing octocrylene. Alternatively, a person can perform a patch test before using a product containing octocrylene for the first time. The patch test should indicate if an individual is allergic or sensitive to an ingredient in the product.
The Food and Drug Administration (FDA) evaluated the safety of octocrylene for use in sunscreen products and found that concentrations of up to 10% are safe.
The European Scientific Committee on Consumer Safety (SCCS) also stated that octocrylene is safe in products containing concentrations of no more than 10%.
Berardesca, E.,et al.(2019). Review of the safety of octocrylene used as an ultraviolet filter in cosmetics.
https://onlinelibrary.wiley.com/doi/full/10.1111/jdv.15945 | | 安全性プロファイル | Low toxicity by ingestion. Whenheated to decomposition it emits toxic vapors of NOx. |
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