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| | 6-AMINO-3,5-DINITROPYRIDINE Basic information | | Preparation |
| Product Name: | 6-AMINO-3,5-DINITROPYRIDINE | | Synonyms: | 2-AMINO-3,5-DINITROPYRIDINE;3,5-Dinitro-2-aminopyridine;6-AMINO-3,5-DINITROPYRIDINE;3,5-dinitropyridin-2-amine;3,5-Dinitro-pyridin-2-ylaMine;2-Pyridinamine,3,5-dinitro-;6-AMINO-3,5-DINITROPYRIDINE ISO 9001：2015 REACH;3,5-Dinitro-2-pyridinamine | | CAS: | 3073-30-1 | | MF: | C5H4N4O4 | | MW: | 184.11 | | EINECS: | 200-258-5 | | Product Categories: | Pyridine series | | Mol File: | 3073-30-1.mol |  |
| | 6-AMINO-3,5-DINITROPYRIDINE Chemical Properties |
| Melting point | 191-192 °C | | Boiling point | 403.1±40.0 °C(Predicted) | | density | 1.694±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -1.68±0.49(Predicted) |
| HazardClass | IRRITANT-HARMFUL |
| | 6-AMINO-3,5-DINITROPYRIDINE Usage And Synthesis |
| Preparation | Ritter202 found that nitration of 2-amino-5-nitropyridine gave the 2-nitrarnino compound and further reaction gave 2-amino-3,5-dinitropyridine. | | Uses | 3,5-Dinitro-2-pyridinamine can be used to prepare antagonists for NMDA/glycine, AMPA, and Kainate Receptors. | | Synthesis | The general procedure for the synthesis of 2-amino-3,5-dinitropyridine from 2-chloro-3,5-dinitropyridine was as follows: 2-chloro-3,5-dinitropyridine (22.3 g, 0.11 mol) was slowly added to a methanol solution of ammonia (7N, 150 mL) in batches at a low temperature of 5-10 °C. The reaction mixture was stirred continuously for 1 h at room temperature and subsequently poured into water (500 mL) to terminate the reaction. The resulting solid product was collected by filtration and washed with cold water (100 mL) to remove impurities. Finally, the product was dried to afford 2-amino-3,5-dinitropyridine (19.55 g, 97% yield), which was used directly in the subsequent reaction without further purification. | | References | [1] Beilstein Journal of Organic Chemistry, 2017, vol. 13, p. 2854 - 2861
[2] Journal of Organic Chemistry, 1985, vol. 50, # 4, p. 484 - 487
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 22, p. 3679 - 3686
[4] Patent: WO2009/111277, 2009, A1. Location in patent: Page/Page column 53
[5] Patent: US2004/116466, 2004, A1 |
| | 6-AMINO-3,5-DINITROPYRIDINE Preparation Products And Raw materials |
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