| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10625
CAS:137346-42-0
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
| Products Intro: |
Product Name:7-nitro-10-octyl-3-phenyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
CAS:137346-42-0
Purity:NULL Package:1mg;2.5mg Remarks:NULL
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:CAY10625
CAS:137346-42-0
Purity:95.00% Package:1mg;5mg;10mg
|
|
| | CAY10625 Basic information |
| Product Name: | CAY10625 | | Synonyms: | CAY10625;7-nitro-10-octyl-3-phenylpyrimido[4,5-b]quinoline-2,4-dione;Pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione, 7-nitro-10-octyl-3-phenyl-;Antitumor agent-144 | | CAS: | 137346-42-0 | | MF: | C25H26N4O4 | | MW: | 446.5 | | EINECS: | | | Product Categories: | | | Mol File: | 137346-42-0.mol |  |
| | CAY10625 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 0.5 mg/ml | | form | A crystalline solid |
| | CAY10625 Usage And Synthesis |
| Description | Survivin is a cellular protein implicated in cell survival by interacting with and inhibiting the apoptotic function of several proteins including Smac/DIABLO, caspase-3, and caspase-7.1,2 Survivin also plays a role in the regulation of the cell cycle as part of a protein complex that includes INCENP, Aurora B kinase, and Borealin. CAY10625 is an antagonist of the interaction between survivin and the apoptosis-promoting protein Smac/DIABLO, exhibiting an IC50 value of 2.2 μM.3 It inhibits the interaction of survivin with INCENP less effectively with an IC50 value of 20 μM. CAY10625 is cell-permeable and sensitizes cells to the induction of apoptosis by doxorubicin.3 | | Uses | Antitumor agent-144 (16) is an antitumor agent, with IC50 values of 2.6 μM and 8.4 μM in L1210 and KB cells, respectively[1]. | | Definition | ChEBI: CAY10625 is a nitro compound and a member of quinolines. | | References | 1. Ryan, B.M., O'Donovan, N., and Duffy, M.J. Survivin: A new target for anti-cancer therapy Cancer Treat. Rev. 35,553-562(2009).
2. Shin, S., Sung, B.J., Cho, Y.S., et al. An anti-apoptotic protein human survivin is a direct inhibitor of caspase-3 and -7 Biochemistry 40,1117-1123(2001).
3. Oikawa, T., Unno, Y., Matsuno, K., et al. Identification of a small-molecule inhibitor of the interaction between Survivin and Smac/DIABLO Biochem. Biophys. Res. Commun. 393,253-258(2010). |
| | CAY10625 Preparation Products And Raw materials |
|