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JNJ 31020028

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:JNJ 31020028
CAS:1094873-14-9
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name: JNJ 31020028
CAS: 1094873-14-9
Purity:95%~99% Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:JNJ-31020028；JNJ 31020028;JNJ31020028
CAS:1094873-14-9
Purity:95.92% Package:1 mg；1 mL * 10mM (in DMSO)；10 mg；2 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:JNJ-31020028
CAS:1094873-14-9
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:JNJ-31020028
CAS:1094873-14-9
Purity:98% Package:1mg Remarks:V2943

JNJ 31020028 manufacturers

  • JNJ 31020028
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  • $1.00 / 1KG
  • 2019-09-06
  • CAS: 1094873-14-9
  • Min. Order: 1KG
  • Purity: 95%~99%
  • Supply Ability: per week 100kg
JNJ 31020028 Basic information
Product Name:JNJ 31020028
Synonyms:JNJ 31020028;N-(4-(4-(2-(diethylamino)-2-oxo-1-phenylethyl)piperazin-1-yl)-3-fluorophenyl)-2-(pyridin-3-yl)benzamide;N,N-Diethyl-4-[2-fluoro-4-[[2-(3-pyridinyl)benzoyl]amino]phenyl]-alpha-phenyl-1-piperazineacetamide;4-[1-(BENZENESULFONYL)-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRROLO[2,3-B]PYRIDIN-2-YL]BENZALDEHYDE;JNJ31020028, >98%;JNJ-31020028?, >98%;CS-1745;JNJ-31020028;JNJ 31020028
CAS:1094873-14-9
MF:C34H36FN5O2
MW:565.68
EINECS:
Product Categories:Inhibitors
Mol File:1094873-14-9.mol
JNJ 31020028 Structure
JNJ 31020028 Chemical Properties
Boiling point 677.5±55.0 °C(Predicted)
density 1.228±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 21.5 mg/mL (38.01 mM; Need ultrasonic and warming)
form Powder
pka12.14±0.70(Predicted)
Safety Information
MSDS Information
JNJ 31020028 Usage And Synthesis
DescriptionJNJ-31020028 is a brain-permeable selective antagonist of the neuropeptide Y (NPY) receptor Y2 (IC50s = 8.51, 6.03, and 6.17 nM for human, rat, and mouse receptors, respectively) with over 100-fold selectivity for Y2 over Y1, Y4, and Y5 receptors. JNJ-31020028 inhibits calcium release induced by peptide YY in a functional assay in KAN-TS cells (pKB = 8.04) and blocks NPY(13-36)-induced decreases in twitch contraction amplitude in isolated rat vas deferens (IC50 = 7.94 nM). Administration of JNJ-31020028 to rats during abstinence (20 mg/kg per day, i.p.) reverses nicotine-induced social anxiety-like behavior and increases hippocampal Y2 receptor mRNA levels. It reverses withdrawal-induced anxiety-like behavior in rats in the elevated plus maze following a single bolus dose of alcohol when administered at a dose of 15 mg/kg. In an olfactory bulbectomized rat model of depression, chronic JNJ-31020028 treatment (10 nmol per day, i.c.v.) decreases immobility time in the forced swim test but has no effect in control animals.
JNJ 31020028 Preparation Products And Raw materials
Tag:JNJ 31020028(1094873-14-9) Related Product Information
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