| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro-
CAS:313964-19-1
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
|
| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:HIF-2α-IN-3
CAS:313964-19-1
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:HIF-2α-IN-3
CAS:313964-19-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
|
| | 2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Basic information |
| | 2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Chemical Properties |
| Boiling point | 505.6±60.0 °C(Predicted) | | density | 1.726±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 12.5 mg/mL (37.24 mM; Need ultrasonic) | | pka | -2.92±0.48(Predicted) |
| | 2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Usage And Synthesis |
| Biological Activity | HIF-2α-IN-3, an allosteric inhibitor of hypoxia inducible factor-2α (HIF-2α), exhibits an IC50 of 0.4 μM and a KD of 1.1 μM. Anticancer agent[1].
HIF-2α-IN-3 (Compound 1) inhibit HIF-2α-ARNT (also known as HIF-β) heterodimerization by binding an internal cavity of the HIF-2α PAS-B domain[1]. | | References | [1]. Rogers JL, et al. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. J Med Chem. 2013 Feb 28;56(4):1739-47. |
| | 2,1,3-Benzoxadiazol-5-aMine, N-(4-chloro-3-nitrophenyl)-4-nitro- Preparation Products And Raw materials |
|