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| | 4-Amino-2-chloro-5-nitrobenzotrifluoride Basic information | | Synthesis |
| Product Name: | 4-Amino-2-chloro-5-nitrobenzotrifluoride | | Synonyms: | 5-CHLORO-2-NITRO-4-(TRIFLUOROMETHYL)ANILINE;5-chloro-2-nitro-4-trifluoroMethyl-phenylaMine;5-Chloro-2-nitro-4-(trifluoromethyl)aniline, 2-Amino-4-chloro-5-(trifluoromethyl)nitrobenzene;Benzenamine, 5-chloro-2-nitro-4-(trifluoromethyl)-;5-Chloro-2-nitro-4-(trifluoromethyl)benzenamine;5-chloro-4-(trifluoromethyl)-2-nitrobenzenamine;5-chloro-2-nitro-5-trifluoromethylaniline;4-Amino-2-chloro-5-nitrobenzotrifluoride 97% | | CAS: | 35375-74-7 | | MF: | C7H4ClF3N2O2 | | MW: | 240.57 | | EINECS: | | | Product Categories: | | | Mol File: | 35375-74-7.mol |  |
| | 4-Amino-2-chloro-5-nitrobenzotrifluoride Chemical Properties |
| Melting point | 113 °C | | Boiling point | 310.7±42.0 °C(Predicted) | | density | 1.614±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | -3.78±0.25(Predicted) | | Appearance | Light brown to yellow Solid |
| | 4-Amino-2-chloro-5-nitrobenzotrifluoride Usage And Synthesis |
| Synthesis | We used 5-chloro-2-nitroaniline as a starting material and obtained the intermediate 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE in a relatively high yield through a four-step reaction involving iodination, acetylation protection, trifluoromethylation, and deacetylation. Through continuous experimentation, the yield of the trifluoromethylation step was found to be as high as 78%. The synthesis of 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE mainly involves four steps: iodination, acetylation protection, trifluoromethylation, and deacetylation. The synthetic route is shown in Figure 1. 
Synthetic Route of 5-Chloro-2-nitro-4-(trifluoromethyl)aniline Using 5-chloro-2-nitroaniline and elemental iodine as raw materials, the pesticide intermediate 4-AMINO-2-CHLORO-5-NITROBENZOTRIFLUORIDE is synthesized through a four-step reaction involving iodination, acetylation protection, trifluoromethylation, and deacetylation. This method has the following outstanding features: ① The raw materials are inexpensive and readily available; ② The reaction conditions are mild and easy to control; ③ The reaction system is simple, and the intermediate is easy to separate and purify; ④ The single-step yield is high, and the overall yield is moderate, showing potential development and application value. | | Uses | 5-Chloro-2-nitro-4-(trifluoromethyl)aniline is a reagent used in the preparation of fused imidazole biocides. |
| | 4-Amino-2-chloro-5-nitrobenzotrifluoride Preparation Products And Raw materials |
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