2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
生物活性靶点体内研究 用途与合成方法 MSDS 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate价格(试剂级) 上下游产品信息
| 中文名称 | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate |
|---|---|
| 中文同义词 | 化合物CLP-290;(Z)-5-氟-2-((4-氧代-2-(四氢哒嗪-1(2H)-基)噻唑-5(4H)-亚基)甲基)苯基吡咯烷-1-羧酸酯;吡咯烷-1-甲酸[(Z)-5-氟-2-[[4-氧代-2-[四氢哒嗪-1(2H)-基]噻唑-5(4H)-亚基]甲基]苯基]酯;CLP-290,K + / CL-共转运蛋白2(KCC2)激活剂 |
| 英文名称 | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate |
| 英文同义词 | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate;CLP-290;(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate;[5-Fluoro-2-[(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methyl]phenyl] pyrrolidine;CLP 290;CLP290;2-([(5Z)-2-(1,2-DIAZINAN-1-YL)-4-OXO-4,5-DIHYDRO-1,3-THIAZOL-5-YLIDENE]METHYL)-5-FLUOROPHENYL PYRROL;1-Pyrrolidinecarboxylic acid, 5-fluoro-2-[(Z)-[4-oxo-2-(tetrahydro-1(2H)-pyridazinyl)-5(4H)-thiazolylidene]methyl]phenyl ester;5-Fluoro-2-(Z)-(2-hexahydropyridazin-1-yl-4-oxo-thiazol-5-ylidene)methylphenyl pyrrolidine-1-carboxylate |
| CAS号 | 1181083-81-7 |
| 分子式 | C19H21FN4O3S |
| 分子量 | 404.46 |
| EINECS号 | 604-604-1 |
| 相关类别 | |
| Mol文件 | 1181083-81-7.mol |
| 结构式 | ![2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 结构式](CAS/20150408/GIF/1181083-81-7.gif) |
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 性质
| 沸点 | 553.7±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.47±0.1 g/cm3(Predicted) |
| 储存条件 | 2-8°C(protect from light) |
| 溶解度 | DMSO:23.74(最大浓度 mg/mL);58.7(最大浓度 mM) DMSO:PBS (pH 7.2) (1:6):1.0(最大浓度 mg/mL);2.47(最大浓度. mM) DMF:1.0(最大浓度 mg/mL);2.47(最大浓度 mM) 乙醇:2.02(最大浓度 mg/mL);4.99(最大浓度 mM) |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 1.29±0.20(Predicted) |
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate 用途与合成方法
CLP290 是一种神经特异性 K+-Cl− 共转运体 KCC2 的口服激活剂，具有研究多种神经和精神疾病的潜力。CLP290 能显著降低 STZ 大鼠的血液中 AVP 和血糖水平。
KCC2
CLP290 (oral gavage; 100 mg/kg; twice a day; 7 day) enhances KCC2 activity and restores Cl - transport in superficial dorsal horn (SDH) neurons of morphine-treated rats, and prevents morphine-induced hyperalgesia (MIH) in rat.
| Animal Model: | Adult male rats (300 g, >postnatal day 60) |
| Dosage: | 100 mg/kg |
| Administration: | Oral gavage; 100 mg/kg; twice a day; 7day |
| Result: | Rescued established MIH and prevented its development by restoring Cl - transport or preventing its deficiency in the SDH. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-103023 | CLP290 | 1 mg | 377元 | |
| 2024/01/25 | HY-103023 | 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate CLP290 | 1181083-81-7 | 10mM * 1mLin DMSO | 740元 |