| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-164-7117 13681763483 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:2-(Dimethylamino)-N-(1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide
CAS:1414854-42-4
Purity:99% Package:5mg;10mg;25mg;50mg Remarks:BD01309647
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Verosudil manufacturers
- Verosudil
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- $53.00 / 1mg
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2025-11-11
- CAS:1414854-42-4
- Min. Order:
- Purity: 99.72%
- Supply Ability: 10g
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| | Verosudil Basic information |
| Product Name: | Verosudil | | Synonyms: | Verosudil;N-(1,2-Dihydro-1-oxo-6-isoquinolinyl)-alpha-(dimethylamino)-3-thiopheneacetamide;Verosudil(AR-12286);3-Thiopheneacetamide, N-(1,2-dihydro-1-oxo-6-isoquinolinyl)-α-(dimethylamino)-;Verosudil, 10 mM in DMSO;2-(Dimethylamino)-N-(1-oxo-1,2-dihydroisoquinolin-6-yl)-2-(thiophen-3-yl)acetamide | | CAS: | 1414854-42-4 | | MF: | C17H17N3O2S | | MW: | 327.4 | | EINECS: | | | Product Categories: | | | Mol File: | 1414854-42-4.mol |  |
| | Verosudil Chemical Properties |
| Boiling point | 625.5±55.0 °C(Predicted) | | density | 1.328±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:0.0(Max Conc. mg/mL);0.0(Max Conc. mM) | | pka | 13.70±0.20(Predicted) | | form | Solid | | color | White to light yellow |
| | Verosudil Usage And Synthesis |
| Uses | Verosudil (AR-12286) is a potent, selective Rho-kinase (ROCK) inhibitor with Kis of 2 and 2 nM for ROCK1 and ROCK2, respectively. AR-12286 lowers intraocular pressure (IOP) primarily by increasing aqueous humour outflow through the trabecular meshwork[1][2]. | | IC 50 | ROCK1: 2 nM (Ki); ROCK2: 2 nM (Ki); PKA: 69 nM (Ki); MRCKA: 28 nM (Ki); CAM2A: 5855 nM (Ki); PKC theta: 9322 nM (Ki) | | References | [1] Lin CW, Sherman B, Moore LA, et al. Discovery and Preclinical Development of Netarsudil, a Novel Ocular Hypotensive Agent for the Treatment of Glaucoma. J Ocul Pharmacol Ther. 2018;34(1-2):40‐51. DOI:10.1089/jop.2017.0023
[2] Kopczynski C, Novack GD, Swearingen D, van Haarlem T. Ocular hypotensive efficacy, safety and systemic absorption of AR-12286 ophthalmic solution in normal volunteers. Br J Ophthalmol. 2013;97(5):567‐572. DOI:10.1136/bjophthalmol-2012-302466 |
| | Verosudil Preparation Products And Raw materials |
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