| Company Name: |
Haoyuan Chemexpress Co., Ltd.
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| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:BHPI
CAS:56632-39-4
Purity:>98% Package:2333RMB/2mg
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| Product Name: | BHPI | | Synonyms: | BHPI;2H-Indol-2-one, 1,3-dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-;1,3-Dihydro-3,3-bis(4-hydroxyphenyl)-7-methyl-2H-indol-2-one;CS-2134 | | CAS: | 56632-39-4 | | MF: | C21H17NO3 | | MW: | 331.36 | | EINECS: | | | Product Categories: | | | Mol File: | 56632-39-4.mol |  |
| Melting point | 272-274 °C | | Boiling point | 557.7±50.0 °C(Predicted) | | density | 1.320±0.06 g/cm3(Predicted) | | solubility | DMF: 5 mg/ml; DMSO: 11 mg/ml; Ethanol: 14 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 9.43±0.30(Predicted) |
| Description | BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial, and ovarian cancer cell lines at concentrations ranging from 10 to 1,000 nM. It is effective in vivo, driving tumor regression in mice bearing MCF-7 xenografts at a dose of 15 mg/kg daily. BHPI specifically inhibits ERα-dependent gene expression and protein synthesis by activating the unfolded protein response in cells. | | Uses | BHPI is an antagonist of estrogen receptor α (ERα) that blocks 17β-estradiol-induced proliferation of drug-resistant breast, endometrial and ovarian cancer cell lines. | | storage | Store at -20°C |
| | BHPI Preparation Products And Raw materials |
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