| Company Name: |
BOC Sciences
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1-631-485-4226; 16314854226 |
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info@bocsci.com |
| Products Intro: |
Product Name:BML-278
CAS:120533-76-8
Purity:>=95% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai ChuangYan Chemical Technology Co., Ltd.
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| Tel: |
021-11111111 11111111111 |
| Email: |
546919421@qq.com |
| Products Intro: |
Product Name:diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
CAS:120533-76-8
Purity:95+ Package:1g,5g,10g,25g,50g,100g
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| | diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Basic information |
| Product Name: | diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate | | Synonyms: | diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate;DI ETHYL 1 BENZYL 4 PHENYL 4H PYRIDINE 3-5 DICARBOXYLATE;Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate;BML-278;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-phenyl-1-(phenylmethyl)-, 3,5-diethyl ester;BML278|||BML 278;BML-278, SIRT activator | | CAS: | 120533-76-8 | | MF: | C24H25NO4 | | MW: | 391.46 | | EINECS: | | | Product Categories: | | | Mol File: | 120533-76-8.mol |  |
| | diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Chemical Properties |
| Melting point | 139-141 °C(Solv: cyclohexane (110-82-7); benzene (71-43-2)) | | Boiling point | 525.5±50.0 °C(Predicted) | | density | 1.183±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO (up to 5 mg/ml). | | form | solid | | pka | 2.05±0.70(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Usage And Synthesis |
| Description | BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable. | | Uses | Diethyl 1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a cell-permeable and potent SIRT activator that induces cell cycle arrest. SIRT modulators have therapeutic potential the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases. | | Definition | ChEBI: 4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine. | | Synthesis | A mixture of benzaldehyde (0.05 mol), ethyl propargylate (0.10 mol), benzylamine (0.05 mol) and 5.0 mL of acetic acid was heated in a steam bath for 25 min [16,17]. After completion of the reaction, the crude product was purified by crystallization with a solvent mixture of methanol and water (4:1, v/v) followed by recrystallization with a solvent mixture of acetone and hexane (1:1, v/v) to give diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate. | | References | [1] ANTONELLO MAI*. Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors[J]. Journal of Medicinal Chemistry, 2009, 52 17: 5496-5504. DOI:10.1021/jm9008289 |
| | diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Preparation Products And Raw materials |
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