APICIDIN

APICIDIN Suppliers list
Company Name: Alpha Biopharmaceuticals Co., Ltd
Tel: 0086-411-39042497
Email: sales@alphabiopharm.com
Products Intro: Product Name:APICIDIN
CAS:183506-66-3
Purity:>98% HPLC Package:5mg; 25mg; 100mg; 1g; 5g; 25g;100g Remarks:B0178
Company Name: HENAN BON INDUSTRIAL CO.,LTD
Tel: 0371-55170695
Email: info@hnbon.com
Products Intro: CAS:183506-66-3
Purity:0.99 Package:25KG;5KG;1KG;500G
Company Name: Fuxin Pharmaceutical
Tel: 021-50872116
Email: contact@fuxinpharm.com
Products Intro: Product Name:Apicidin
CAS:183506-66-3
Purity:99% Package:1kg; 25kg; or larger package as required
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: 86-021-61999440
Email: contact@trustwe.com
Products Intro: Product Name:Apicidin
CAS:183506-66-3
Purity:98% Package:Package as requetsed
Company Name: Target Molecule Corp
Tel: 781-999-5354
Email: marketing@targetmol.com
Products Intro: Product Name:Apicidin;OSI 2040
CAS:183506-66-3
Purity:98.00% Package:1 mg;5 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
APICIDIN Basic information
Product Name:APICIDIN
Synonyms:Apicidin (OSI 2040);APICIDIN, FUSARIUM SPECIES;Ccris 9163;Apicidin Ia;Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl- D-2-piperidinecarbonyl);Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl];OSI 2040;Apicidin Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
CAS:183506-66-3
MF:C34H49N5O6
MW:623.78
EINECS:
Product Categories:antibiotic
Mol File:183506-66-3.mol
APICIDIN Structure
APICIDIN Chemical Properties
density 1.27±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility DMSO: ~1mg/mL
form solid
pka13.09±0.70(Predicted)
Safety Information
Hazard Codes T+
Risk Statements 26/27/28
Safety Statements 22-26-36/37/39-45
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
HS Code 29419090
MSDS Information
ProviderLanguage
SigmaAldrich English
APICIDIN Usage And Synthesis
Chemical PropertiesSolid
UsesApicidin is a potent (nM) cell permeable inhibitor of histone deacetylase. Also, Apicidin exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin.
UsesApicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis.
Enzyme inhibitorThis fungal metabolite and potential oral chemotherapeutic agent (FW = 623.79 g/mol; CAS 183506-66-3), also known as [cyclo(N-O-methyl-L- tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)], is an antiprotozoal agent. It is cell permeable and is a strong inhibitor of histone deacetylase (IC50 = 0.7 nM). Apicidin also inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Apicidin’s low bioavailability of apicidin is mainly due to the P-gycoprotein-mediated efflux.
APICIDIN Preparation Products And Raw materials
Tag:APICIDIN(183506-66-3) Related Product Information
Tubacin Entinostat HC TOXIN M344 Parthenolide Apicidin, Fusarium sp. ETHYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE BUTYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE N-[(1-BUTYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE BUTYL[(1-BUTYLPIPERIDIN-2-YL)METHYL]AMINE N-[(1-ETHYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE N-[(1-PROPYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE BUTYL[(1-PROPYLPIPERIDIN-2-YL)METHYL]AMINE BUTYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE APICIDIN N-[(1-METHYL-2-PIPERIDINYL)METHYL]-1-PROPANAMINE Cyclen N-[(1-BUTYL-2-PIPERIDINYL)METHYL]ETHANAMINE