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| | APICIDIN Basic information |
| Product Name: | APICIDIN | | Synonyms: | Apicidin
(OSI 2040);APICIDIN, FUSARIUM SPECIES;Ccris 9163;Apicidin Ia;Cyclo(8-oxo-L-2-aMinodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-
D-2-piperidinecarbonyl);Cyclo[(2S)-2-aMino-8-oxodecanoyl-1-Methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl];OSI 2040;Apicidin Cyclo[(2S)-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl] | | CAS: | 183506-66-3 | | MF: | C34H49N5O6 | | MW: | 623.78 | | EINECS: | | | Product Categories: | antibiotic | | Mol File: | 183506-66-3.mol |  |
| | APICIDIN Chemical Properties |
| density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | −20°C
| | solubility | DMSO: ~1mg/mL | | form | solid
| | pka | 13.09±0.70(Predicted) |
| | APICIDIN Usage And Synthesis |
| Chemical Properties | Solid | | Uses | Apicidin is a potent (nM) cell permeable inhibitor of histone deacetylase. Also, Apicidin exhibits antiprotozoal and potential antimalarial properties. Apicidin has antiproliferative activity on HeLa
cells accompanied by cell arrest at the G1 phase. Apicidin induces selective changes in the expression of p21 and gelsolin. | | Uses | Apicidin is a cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. Apicidin, a histone deacetylase inhibitor, is anti-angiogenic and induces apoptosis. | | Enzyme inhibitor | This fungal metabolite and potential oral chemotherapeutic agent (FW = 623.79 g/mol; CAS 183506-66-3), also known as [cyclo(N-O-methyl-L- tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl)], is an antiprotozoal agent. It is cell permeable and is a strong inhibitor of histone deacetylase (IC50 = 0.7 nM). Apicidin also inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Apicidin’s low bioavailability of apicidin is mainly due to the P-gycoprotein-mediated efflux. |
| | APICIDIN Preparation Products And Raw materials |
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