Volixibat potassium
| 中文名称 | Volixibat potassium |
|---|---|
| 中文同义词 | 单链尿激酶纤溶酶原激活剂八肽;化合物 T26629;单链尿激酶纤溶酶原激活剂多肽 |
| 英文名称 | Volixibat potassium |
| 英文同义词 | Volixibat potassium;Angstrom6/A6 Peptide;A-6 peptide;L-α-Glutamine, N2-acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl-L-prolyl-L-α-glutamyl-;P1161 Angstrom6 |
| CAS号 | 220334-14-5 |
| 分子式 | C39H62N10O15 |
| 分子量 | 910.98 |
| EINECS号 | |
| 相关类别 | 定制多肽 |
| Mol文件 | 220334-14-5.mol |
| 结构式 |  |
Volixibat potassium 性质
| 沸点 | 1469.3±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.409±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 酸度系数(pKa) | 4.44±0.10(Predicted) |
Angstrom6 (A6 Peptide) 是一种来源于单链尿激酶纤溶酶原激活剂 (scuPA) 的8个氨基酸的肽，可干扰 uPA/uPAR 级联反应并消除下游效应。Angstrom6 与 CD44 结合，抑制肿瘤细胞的迁移、侵袭和转移，调节 CD44 介导的细胞信号。
Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC
50
s in the range of 10 to 100 nM.
Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation.
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%.
| Animal Model: | C57Bl/6 mice (bearing B16-F10 cells) |
| Dosage: | 100 mg/kg |
| Administration: | S.c.; twice a day for 11 days |
| Result: | Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control. |