| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:JAK2 JH2 Tracer
CAS:2101955-00-2
Purity:60RMB/5mg Package:>98%
|
| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:JAK2 JH2 Tracer
CAS:2101955-00-2
Purity:98% Package:1mg;5mg;10mg;50mg
|
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| | JAK2 JH2 Tracer Basic information |
| Product Name: | JAK2 JH2 Tracer | | Synonyms: | JAK2 JH2 Tracer;Thiourea, N-[[4-[[5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]phenyl]methyl]-N'-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-N-methyl- | | CAS: | 2101955-00-2 | | MF: | C38H27F2N7O6S | | MW: | 747.73 | | EINECS: | | | Product Categories: | | | Mol File: | 2101955-00-2.mol |  |
| | JAK2 JH2 Tracer Chemical Properties |
| Boiling point | 985.4±75.0 °C(Predicted) | | density | 1.58±0.1 g/cm3(Predicted) | | pka | 9.33±0.20(Predicted) | | form | Solid | | color | Light brown to brown |
| | JAK2 JH2 Tracer Usage And Synthesis |
| Uses | JAK2 JH2 Tracer (Tracer 5) is a fluorescent probe for JAK2 JH2 domain, with a Kd of value 0.2 μM[1][2]. | | in vivo | The possibility that mutations within the JAK2 JH2 domain may be associated with pathology, which is associated with a hyperactive kinase and a hematopoietic malignancy phenotype in flies[2]. Specific mutation in the JAK2 JH2 domain is associated with several myeloproliferative diseases[2]. | | References | [1] Newton AS, et al. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett. 2017 May 17;8(6):614-617. DOI:10.1021/acsmedchemlett.7b00154
[2] Ihle JN, Gilliland DG. Jak2: normal function and role in hematopoietic disorders. Curr Opin Genet Dev. 2007 Feb;17(1):8-14. DOI:10.1016/j.gde.2006.12.009 |
| | JAK2 JH2 Tracer Preparation Products And Raw materials |
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