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ChemicalBook Optimization Suppliers |
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| 化学名: | | | 英語化学名: | CU-CPT-9a | | 别名: | CPD1577;CU-CPT-9a;2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol;cas 2162962-69-6;CU-CPT-9A;CAS 2162962-69-6;TLR8 INHIBITOR;TLR8 inhibitor;TLR8-specific antagonist 1;4-(4-hydroxy-3-methylphenyl)quinolin-7-ol | | CAS番号: | 2162962-69-6 | | 分子式: | C16H13NO2 | | 分子量: | 251.28 | | EINECS: | | | カテゴリ情報: | | | Mol File: | 2162962-69-6.mol |  |
| 沸点 | 452.6±45.0 °C(Predicted) | | 比重(密度) | 1.287±0.06 g/cm3(Predicted) | | 貯蔵温度 | Store at -20°C | | 溶解性 | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | | 外見 | A crystalline solid | | 酸解離定数(Pka) | 8.46±0.20(Predicted) |
| | CU-CPT-9a Usage And Synthesis |
| 説明 | CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM. | | 使用 | CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. |
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