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| 化学名: | クエルセチン·2水和物 | | 英語化学名: | Quercetin dihydrate | | 别名: | QUERCETIN DIHYDRATE;3,5,7,3',4'-PENTAHYDROXYFLAVONE DIHYDRATE;3,3’,4’,5,7-pentahydroxy-flavondihydrate;Flavone,3,3’,4’,5,7-pentahydroxy-,dihydrate;2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-4H-1-BENZOPYRAN-4-ONE DIHYDRATE;3,3',4',5,7-PENTAHYDROXYFLAVONE 2H2O;3,3',4',5,7-PENTAHYDROXYFLAVONE DIHYDRATE;3,3',4',5,7-PENTAHYDROXYFLAVONE HYDRATE | | CAS番号: | 6151-25-3 | | 分子式: | C15H14O9 | | 分子量: | 338.27 | | EINECS: | 612-158-3 | | カテゴリ情報: | Flavanols;Biochemistry;Flavonoids;C15 to C38;Carbonyl Compounds;Ketones;Signalling;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors;Inhibitors;TROXEPURE | | Mol File: | 6151-25-3.mol |  |
| 融点 | >300 °C(lit.) | | 比重(密度) | 1.680 g/cm3 | | 貯蔵温度 | -20°C | | 溶解性 | Soluble in DMSO > 10 mM | | 外見 | Yellow solid | | カラーインデックス | 75670 | | 色 | Yellow | | 水溶解度 | practically insoluble | | Merck | 14,8034 | | BRN | 317313 | | InChIKey | GMGIWEZSKCNYSW-UHFFFAOYSA-N | | LogP | 2.075 (est) | | CAS データベース | 6151-25-3(CAS DataBase Reference) |
| 主な危険性 | T | | Rフレーズ | 25-46-23/24/25 | | Sフレーズ | 45-53 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS 番号 | LK8950000 | | TSCA | Yes | | 国連危険物分類 | 6.1 | | 容器等級 | III | | HSコード | 29329990 | | 毒性 | LD50 orally in mice: 160 mg/kg (Sullivan) |
| | クエルセチン·2水和物 Usage And Synthesis |
| 外観 | 黄色～暗黄褐色、粉末又は塊 | | 溶解性 | エタノール, 酢酸にやや易溶, 水にほとんど不溶。 | | 用途 | 分析用(Ge,Zr,U,Sn,Nb,Ta)、薬理、生理作用研究用。 | | 化学的特性 | yellow crystalline powder | | 使用 | bioflavenoid, antioxidant, antiviral, antimicrobial, enzyme inhibitor | | 使用 | capillary protectant, antioxidant. antineoplastic, anti-HIV | | 使用 | Quercetin dihydrate used as a Inhibitor of protein tyrosine kinase, mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. | | 一般的な説明 | Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate. | | Biochem/physiol Actions | Quercetin dihydrate is a flavonoid with anticancer activity. Quercetin is a mitochondrial ATPase and phosphodiesterase inhibitor. It Inhibits PI3-kinase activity and slightly inhibits PIP kinase activity. Quercetin has antiproliferative effects on cancer cell lines, reduces cancer cell growth via type II estrogen receptors, and arrests human leukemic T cells in late G1 phase of the cell cycle. | | target | HMG-CoA Reductase | SOD | Antifection | | 貯蔵 | Room temperature | | 純化方法 | Crystallise the flavone from aqueous EtOH and dry at 100o. It also sublimes in a vacuum. IR: 2.5 and 16.7 (KBr). max It complexes with Cu2+, Al3+, Ca2+, Ge4+, Zn2+, Ti4+, Zr4+, Th4+, UO4+ . [Beilstein 18 H 242, 18 I 242, 18 II 236, 18 III/IV 3470, 18/5 V 494.] |
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