C16 3'-sulfo Galactosylceramide (d18:1/16:0)

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C16 3'-sulfo Galactosylceramide (d18:1/16:0) Basic information
Product Name:C16 3'-sulfo Galactosylceramide (d18:1/16:0)
Synonyms:C16 3'-sulfo Galactosylceramide (d18:1/16:0);-sulfo Galactosylceramide (d18:1/16:0);C16 3’Hexadecanamide, N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-β-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-;N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-β-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-hexadecanamide;N-Hexadecanoylsulfatide, C16:0 CNS sulfolipid analog;C16 3′,-sulfo Galactosylceramide (d18:1/16:0)
CAS:89771-78-8
MF:C40H77NO11S
MW:780.10448
EINECS:
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Mol File:89771-78-8.mol
C16 3'-sulfo Galactosylceramide (d18:1/16:0) Structure
C16 3'-sulfo Galactosylceramide (d18:1/16:0) Chemical Properties
density 1.13±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Chloroform:Methanol (2:1): Soluble
form A solid
pka-3.61±0.18(Predicted)
Safety Information
MSDS Information
C16 3'-sulfo Galactosylceramide (d18:1/16:0) Usage And Synthesis
DescriptionC16 3’-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is one of the most abundant sulfatides found in porcine brain and plasma. Levels of short-chain sulfatides, including C16-C20 3’-sulfo galactosylceramides, decrease throughout development in mice. C16 3’-sulfo Galactosylceramide inhibits retinal ganglion cell neurite outgrowth in vitro. It is increased in dried urine spots and dried blood spots from patients with metachromatic leukodystrophy (MLD). C16 3’-sulfo Galactosylceramide has been used as an internal standard for the quantification of sulfatides in rat cerebellum and isolated white matter from patients with multiple sclerosis. [Matreya, LLC. Catalog No. 1875]
UsesPalmitoyl sulfatide is an ester product.
DefinitionChEBI: 1-(3-O-sulfo-beta-D-galactosyl)-N-palmitoylsphingosine is a D-galactosyl-N-acylsphingosine having a sulfo group at the 3-position on the galactose ring and palmitoyl as the N-acyl group. It is a N-acyl-beta-D-galactosylsphingosine and a galactosylceramide sulfate.
References[1] JENNIFER T. SAVILLE . Quantification of plasma sulfatides by mass spectrometry: Utility for metachromatic leukodystrophy[J]. Analytica Chimica Acta, 2017, 955: Pages 79-85. DOI: 10.1016/j.aca.2016.12.002
[2] GIORGIS ISAAC. Sulfatide with short fatty acid dominates in astrocytes and neurons[J]. The FEBS journal, 2006, 273 8: 1782-1790. DOI: 10.1111/j.1742-4658.2006.05195.x
[3] ALISSA M WINZELER. The lipid sulfatide is a novel myelin-associated inhibitor of CNS axon outgrowth.[J]. Journal of Neuroscience, 2011: 6481-6492. DOI: 10.1523/jneurosci.3004-10.2011
[4] MARIANA BARCENAS . Quantification of sulfatides in dried blood and urine spots from metachromatic leukodystrophy patients by liquid chromatography/electrospray tandem mass spectrometry[J]. Clinica Chimica Acta, 2014, 433: Pages 39-43. DOI: 10.1016/j.cca.2013.12.016
[5] BETH NOELLE MARBOIS . Analysis of sulfatide from rat cerebellum and multiple sclerosis white matter by negative ion electrospray mass spectrometry[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2000, 1484 1: Pages 59-70. DOI: 10.1016/s1388-1981(99)00201-2
C16 3'-sulfo Galactosylceramide (d18:1/16:0) Preparation Products And Raw materials
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