NKH477
| 中文名称 | NKH477 |
|---|---|
| 中文同义词 | 化合物 NKH477;NKH 477 (COLFORSIN DAROPATE),AN ADENYLYL CYCLASE活化剂;NKH 477(达福尔考辛) |
| 英文名称 | N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride |
| 英文同义词 | NKH 477;(3r-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,10a-beta,10b-alpha))-id;N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester b-Alanine hydrochloride;Forskolin, NKH477;beta-alanine,n,n-dimethyl-,5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydrox;colforsindapropatehydrochloride;N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester beta-alanine hydrochloride;N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride |
| CAS号 | 138605-00-2 |
| 分子式 | C27H44ClNO8 |
| 分子量 | 546.1 |
| EINECS号 | |
| 相关类别 | Signalling;Cyclic Nucleotide related |
| Mol文件 | 138605-00-2.mol |
| 结构式 |  |
NKH477 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | H2O:3mg/mL,清澈至轻微混浊（加热） |
| 形态 | 白色固体 |
| 颜色 | 白色至米色 |
| 水溶解性 | Soluble to 40 mM in water |
| InChIKey | VIRRLEDAYYYTOD-YHEOSNBFSA-N |
| SMILES | Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)[C@H]13)C=C |
NKH477 (Colforsin dapropate hydrochloride) 是一种新型水溶性毛喉素衍生物，主要通过对舒张性心脏功能的有益作用来改善心力衰竭。 NKH477 直接激活腺苷酸环化酶 (adenylate cyclase) 的催化单元并增加细胞内 cAMP。 NKH477 在体内抗增殖作用，可以抑制大鼠原位肺同种异体移植物的急性排斥。
Adenylate Cyclase
NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner.
| Animal Model: | Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g |
| Dosage: | 1, 2 or 3 mg/kg/day |
| Administration: | Orally; daily; Days 3 and 5 |
| Result: | Prolonged lung allograft survival in a dose dependent manner. |
安全信息
| 危险品标志 | T+ |
|---|---|
| 危险类别码 | 28 |
| 安全说明 | 28-36/37-45 |
| 危险品运输编号 | UN 2811 6.1 / PGII |
| WGK Germany | 3 |
| RTECS号 | AY5992600 |
| 存储类别 | 6.1A - 可燃，急性毒性物质（类别1和类别2） 剧毒的危险物质 |
| 危险性类别 | 急性毒性 类别2 经口 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-103193 | NKH477 NKH477 | 138605-00-2 | 5mg | 1000元 |
| 2026/09/15 | HY-103193 | NKH477 NKH477 | 138605-00-2 | 10mg | 1800元 |