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ChemicalBook Optimization Suppliers |
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| | LCB 03-0110
(LCB03-0110) 製品概要 |
| 化学名: | | | 英語化学名: | LCB 03-0110
(LCB03-0110) | | 别名: | LCB 03-0110
(LCB03-0110);LCB 03-0110;Phenol, 3-[[2-[3-(4-morpholinylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]-;LCB 03-0110, 10 mM in DMSO | | CAS番号: | 1228102-01-9 | | 分子式: | C24H23N3O2S | | 分子量: | 417.52 | | EINECS: | | | カテゴリ情報: | | | Mol File: | 1228102-01-9.mol |  |
| | LCB 03-0110
(LCB03-0110) 物理性質 |
| 沸点 | 630.3±50.0 °C(Predicted) | | 比重(密度) | 1.332±0.06 g/cm3(Predicted) | | 酸解離定数(Pka) | 9?+-.0.10(Predicted) |
| | LCB 03-0110
(LCB03-0110) Usage And Synthesis |
| 使用 | LCB 03-0110, a thienopyridine derivative, is a potent pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor. LCB 03-0110 suppresses scar formation by inhibiting fibroblast and macrophage activation[1]. | | in vivo | LCB 03-0110 suppresses the accumulation of myofibroblast and macrophage cells in the healing wound and reduced hypertrophic scar formation after wound closing on rabbit ears[1]. | | 参考文献 | [1] Sun X, et, al. LCB 03-0110, a novel pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor, suppresses scar formation by inhibiting fibroblast and macrophage activation. J Pharmacol Exp Ther. 2012 Mar;340(3):510-9. DOI:10.1124/jpet.111.187328 |
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