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Product Name:Nanaomycin A
CAS:52934-83-5
Purity:98% Remarks:Nanaomycin A is an antibiotic produced by Str. rosa subsp. notoensis. It has anti-gram-positive bact
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| | NANAOMYCIN A Basic information |
| Product Name: | NANAOMYCIN A | | Synonyms: | (1s-e)-10-dioxo;1h-naphtho(2,3-c)pyran-3-aceticacid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,;os-3966-a;rosanomycina;Antibiotic OS 3966A, Nanafrocin, 1H-Naphtho[2,3-c]pyran-3-acetic acid,3,4,5,10-tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-(1S,3R)-;(1S)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3β-acetic acid;(1S,3R)-3,4,5,10-Tetrahydro-9-hydroxy-1-methyl-5,10-dioxo-1H-naphtho[2,3-c]pyran-3-acetic acid;OS-3966-A; ROSANOMYCINA | | CAS: | 52934-83-5 | | MF: | C16H14O6 | | MW: | 302.28 | | EINECS: | | | Product Categories: | | | Mol File: | 52934-83-5.mol |  |
| | NANAOMYCIN A Chemical Properties |
| Melting point | 179°C | | Boiling point | 363.32°C (rough estimate) | | density | 1.2514 (rough estimate) | | refractive index | 1.4600 (estimate) | | storage temp. | −20°C | | solubility | insoluble in H2O; ≥15.1 mg/mL in DMSO; ≥31.07 mg/mL in EtOH with ultrasonic | | form | solid |
| Hazard Codes | T | | Risk Statements | 22-24 | | Safety Statements | 36/37-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | QL6127000 |
| | NANAOMYCIN A Usage And Synthesis |
| Definition | ChEBI: A pyranonaphthoquinone antibiotic from strain OS-3966 of Streptomyces rosa var. notoensis. | | Biological Activity | nanaomycin a is a selective inhibitor of dna methyltransferase 3b (dnmt3b) with ic50 value of 500 nm [1].in the biochemical in vitro methylation assay, nanaomycin a showed selective inhibition of dnmt3b but not dnmt1 although it was docked to the catalytic domain of human dnmt1 in a multi-step docking approach. nanaomycin a showed cell viability inhibition in hct116, a549 and hl60 cells with ic50 values of 400 nm, 4100 nm and 800 nm, respectively. it decreased the genomic methylation level of these cells significantly. besides that, nanaomycin a treatment resulted in demethylation of the rassf1a promoter in a549 cells. the demethylation caused by nanaomycin a reactivated the transcription and expression of a silenced tumor suppressor gene [1]. | | target | DNMT3B | | references | [1] kuck d, caulfield t, lyko f, et al. nanaomycin a selectively inhibits dnmt3b and reactivates silenced tumor suppressor genes in human cancer cells. molecular cancer therapeutics, 2010, 9(11): 3015-3023. |
| | NANAOMYCIN A Preparation Products And Raw materials |
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