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| | tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate 製品概要 |
| 化学名: | | | 英語化学名: | tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate | | 别名: | tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3,5-bis[(2-fluorophenyl)methylene]-4-oxo-, ethyl ester;G5-7;antiangiogenic,inhibit,Apoptosis,JAK,Glioma,G-5-7,cycle,G5 7,phase,G57,STAT3,cell,Inhibitor,EGFR,Janus kinase,G5-7,mTOR;JAK2 inhibitor 5-7;G5-7, 10 mM in DMSO;G5-7 ，E0793 | | CAS番号: | 939681-36-4 | | 分子式: | C22H19F2NO3 | | 分子量: | 383.39 | | EINECS: | | | カテゴリ情報: | | | Mol File: | 939681-36-4.mol |  |
| | tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate 物理性質 |
| 貯蔵温度 | Store at -20°C | | 溶解性 | DMSO : 83.33 mg/mL (217.35 mM; Need ultrasonic) | | 外見 | Solid | | 色 | Off-white to light yellow |
| | tert-Butyl 3,5-bis(2-fluorobenzylidene)-4-oxopiperidine-1-carboxylate Usage And Synthesis |
| 使用 | G5-7, an orally active and allosteric JAK2 inhibitor, selectively inhibits JAK2 mediated phosphorylation and activation of EGFR (Tyr1068) and STAT3 by binding to JAK2. G5-7 induces cell cycle arrest, apoptosis and possesses antiangiogenic effect. G5-7 has the potential for glioma study[1]. | | in vivo | G5-7 (10 and 50 mg/kg, oral gavege) decreases VEGF secretion and exerts a potent antiangiogenic effect[1].
| Animal Model: | Cells (4 × 106) in 100 μl of serum-free DMEM were inoculated subcutaneously into 5- to 6-week-old female nude mice[1].
| | Dosage: | 10 and 50 mg/kg. | | Administration: | Oral gavage. | | Result: | Suppresses angiogenesis in tumors. |
| | IC 50 | JAK2 | | 参考文献 | [1] Kunyan He, et al. Blockade of glioma proliferation through allosteric inhibition of JAK2. Sci Signal. 2013 Jul 9;6(283):ra55. DOI:10.1126/scisignal.2003900 |
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