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| Products Intro: |
Product Name:CDK8-IN-1
CAS:1629633-48-2
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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| | CDK8-IN-1 Basic information |
| Product Name: | CDK8-IN-1 | | Synonyms: | CDK8-IN-1;CDK8-IN-16;CDK8IN1,CDK-8-IN-1,CDK8 IN 1;1H-Pyrrole-2-carboxamide, 4-(4-pyridinyl)-3-(trifluoromethyl)- | | CAS: | 1629633-48-2 | | MF: | C11H8F3N3O | | MW: | 255.2 | | EINECS: | | | Product Categories: | | | Mol File: | 1629633-48-2.mol |  |
| | CDK8-IN-1 Chemical Properties |
| Boiling point | 406.2±45.0 °C(Predicted) | | density | 1.429±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 12.46±0.50(Predicted) |
| | CDK8-IN-1 Usage And Synthesis |
| Description | CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM. CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1]. | | References | [1]. Han X, et al. Discovery of potent and selective CDK8 inhibitors through FBDD approach. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4488-4492. |
| | CDK8-IN-1 Preparation Products And Raw materials |
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