N-Mal-N-bis(PEG2-NH-Boc) manufacturers
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| | N-Mal-N-bis(PEG2-NH-Boc) Basic information |
| Product Name: | N-Mal-N-bis(PEG2-NH-Boc) | | Synonyms: | N-Mal-N-bis(PEG2-NH-Boc);5,8,14,17-Tetraoxa-2,11,20-triazaheneicosanedioic acid, 11-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-, 1,21-bis(1,1-dimethylethyl) ester | | CAS: | 2128735-26-0 | | MF: | C29H50N4O11 | | MW: | 630.73 | | EINECS: | | | Product Categories: | | | Mol File: | 2128735-26-0.mol |  |
| | N-Mal-N-bis(PEG2-NH-Boc) Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | solubility | Soluble in DMSO, DCM, DMF | | form | Viscous Liquid | | color | Colorless to light yellow |
| | N-Mal-N-bis(PEG2-NH-Boc) Usage And Synthesis |
| Description | N-Mal-N-bis(PEG2-NH-Boc) is a branched maleimide reagent with a terminal maleimide group and two terminal Boc protected amino groups. Maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule . Boc can be deprotected under acidic conditions. | | Uses | N-Mal-N-bis(PEG2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-Mal-N-bis(PEG2-NH-Boc) Preparation Products And Raw materials |
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