4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Suppliers list

Company Name:	ATK CHEMICAL COMPANY LIMITED
Tel:	+undefined-21-51877795
Email:	ivan@atkchemical.com
Products Intro:	Product Name:RBN012759 CAS:2360851-29-0 Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G

Company Name:	TargetMol Chemicals Inc.
Tel:	+1-781-999-5354; +17819995354
Email:	marketing@targetmol.com
Products Intro:	Product Name:RBN012759 CAS:2360851-29-0 Purity:99.96% Package:1mg;107USD\|5mg;263USD\|10mg;455USD Remarks:REAGENT;FOR LABORATORY USE ONLY

Company Name:	InvivoChem
Tel:	+1-708-310-1919 +1-13798911105
Email:	sales@invivochem.cn
Products Intro:	Product Name:RBN012759 CAS:2360851-29-0 Purity:98% Package:5mg Remarks:V2480

Company Name:	HANGZHOU LEAP CHEM CO., LTD.
Tel:	+86-571-87711850
Email:	market18@leapchem.com
Products Intro:	Product Name:RBN012759 CAS:2360851-29-0 Package:1g; 5g; 25g; 1kg; 5kg; 25kg

Company Name:	Nantong HI-FUTURE Biology Co., Ltd.
Tel:	+undefined18051384581
Email:	sales@chemhifuture.com
Products Intro:	Product Name:RBN012759 CAS:2360851-29-0 Purity:98% HPLC Package:100mg，500mg，1g，5g，10g

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- manufacturers

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Basic information

Product Name:	4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-
Synonyms:	4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-;RBN012759;poly ADP ribose polymerase,pro-tumor,cancer,PARP14,PARP,RBN012759,macrophage,RBN 012759,Inhibitor,inflammatory,inhibit,RBN-012759;7-(Cyclopropylmethoxy)-5-fluoro-2-(((trans-4-hydroxycyclohexyl)thio)methyl)quinazolin-4(1H)-one;RBN012759, 10 mM in DMSO
CAS:	2360851-29-0
MF:	C19H23FN2O3S
MW:	378.46
EINECS:
Product Categories:
Mol File:	2360851-29-0.mol

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Chemical Properties

storage temp.	4°C, protect from light
solubility	DMSO : 250 mg/mL (660.57 mM; Need ultrasonic)
form	A solid
color	White to off-white
InChI	InChI=1S/C19H23FN2O3S/c20-15-7-13(25-9-11-1-2-11)8-16-18(15)19(24)22-17(21-16)10-26-14-5-3-12(23)4-6-14/h7-8,11-12,14,23H,1-6,9-10H2,(H,21,22,24)/t12-,14-
InChIKey	NKZDEFKPZSLQRF-MQMHXKEQSA-N
SMILES	N1C2=C(C(F)=CC(OCC3CC3)=C2)C(=O)NC=1CS[C@@H]1CC[C@@H](O)CC1

Safety Information

MSDS Information

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Usage And Synthesis

Uses	RBN012759 is an inhibitor of PARP14, which is useful in the treatment of cancer and inflammatory diseases.
in vivo	RBN012759 (500 mg/kg BID; p.o.) is well-tolerated in mice with repeat dosing^[1]. ? RBN012759 (100 mg/kg; p.o.) exhibits moderate orally bioavailability (30%) and short plasma half-life (0.4 h) due to moderate clearance (54 mL/min/kg) and low steady-state volume of distribution (1.4 L/kg) in mice^[1].
IC 50	PARP14: <3 nM (IC₅₀); PARP4: 10 μM (IC₅₀); PARP5a: 8 μM (IC₅₀); PARP5b: 10 μM (IC₅₀); PARP6: 4 μM (IC₅₀); PARP7: 4 μM (IC₅₀); PARP8: 20 μM (IC₅₀); PARP10: 1 μM (IC₅₀); PARP11: 1 μM (IC₅₀); PARP12: 5 μM (IC₅₀); PARP15: 3 μM (IC₅₀); PARP16: 6 μM (IC₅₀)

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Preparation Products And Raw materials

Tag:4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-(2360851-29-0) Related Product Information

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.