Product Details
| Product Name:
RBN012759 |
CAS No.:
2360851-29-0 |
| Purity:
99.96% |
Supply Ability:
10g |
| Release date:
2025/11/10 |
Product Introduction
Bioactivity
| Name | RBN012759 |
| Description | RBN012759 inhibits PARP14 protein with an IC50 value of 0.003 μM and is more than 300-fold selective over all PARP family members.[2] |
| In vitro | METHODS: B cells were treated with RBN012759 (1 or 0.33 μM ) and added once daily. Cultures were harvested and counted on day 5 and the supernatant was collected for ELISA.
RESULTS RBN012759 induced a decrease in IgE. [1]
METHODS: RBN0127599 (0.001-10 μM) was tested in IFN-γ stimulated human primary macrophages and RAW264.7 cells to observe the effect of RBN0127599 on the expression of PARP14 protein in vitro.
RESULTS The EC50 value (half-maximal effect concentration) observed in RAW264.7 cells was 10 μM, and in human macrophages it was 8 μM, indicating that RBN0127599 showed effective inhibition of the target PARP14 within these concentration ranges. [2] |
| In vivo | METHODS: RBN012759 (500 mg/kg,i.g) twice daily. Investigators collected plasma samples 2 hours after the last dose (i.e., after the penultimate dose) and on the last day to determine plasma levels of RBN012759 using liquid chromatography-mass spectrometry.
RESULTS RBN012759 was effective in reducing allergen-induced IgE (immunoglobulin E) overproduction and mucus overproduction. treatment with RBN012759 resulted in a decrease in overall mucus scores in lung tissue, while the number of inflammatory cells recovered from bronchoalveolar lavage fluid (BALF) and the proportion of eosinophils recovered were significantly reduced in the bronchial-alveolar lavage fluid (BALF) of RBN012759-treated mice. were significantly reduced. [1]
METHODS: RBN012759 was tested in a C57BL/6 mouse model by oral administration (BID) at doses of 300 mg/kg and 500 mg/kg for 7 days.
RESULTS The 500 mg/kg group showed an increase in PARP14 protein levels, while the 300 mg/kg group did not, indicating that RBN012759 can effectively and specifically target PARP14 in vivo at higher doses. [2] |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 12 mg/mL (31.71 mM), Sonication is recommended.
|
| Keywords | RBN-012759 | RBN012759 | RBN 012759 | pro-tumor | poly ADP ribose polymerase | PARP14 | PARP | macrophage | Inhibitor | inhibit | inflammatory | cancer |
| Inhibitors Related | 4'-Methoxychalcone | VPC-70063 | 3-Aminobenzamide | XAV-939 | Niraparib | Talazoparib | 3-Methoxybenzamide | AZ9482 | NU1025 | Olaparib | Benzamide | OUL35 |
| Related Compound Libraries | DNA Damage & Repair Compound Library | Bioactive Compound Library | Inhibitor Library | Anti-Cardiovascular Disease Compound Library | Anti-Prostate Cancer Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Preclinical Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
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United States