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| | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 製品概要 |
| 化学名: | | | 英語化学名: | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride | | 别名: | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP,;11-Piperazin-1-yl-dibenzo[B,F][1,4]thiazepine dihydrochloride;Dibenzo[b,f][1,4]thiazepine, 11-(1-piperazinyl)-, hydrochloride (1:2);11-PIPERAZIONDIBENZO[b,f][1,4]THIAZEPINE DIHYDROCHLORIDE;dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine;dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dihydrochloride;11-Piperazinodibenzo-[b,f][1,4]-thiazepin;N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine 2HCl | | CAS番号: | 111974-74-4 | | 分子式: | C17H18ClN3S | | 分子量: | 331.86 | | EINECS: | 1312995-182-4 | | カテゴリ情報: | Quetiapine;Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;(intermediate of quetiapine fumarate) | | Mol File: | 111974-74-4.mol | ![11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride](CAS/GIF/111974-74-4.gif) |
| | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 物理性質 |
| 融点 | 180-184°C | | 貯蔵温度 | Inert atmosphere,2-8°C | | 溶解性 | Soluble in DMSO, Methanol, Distilled Water | | 外見 | solid | | 色 | Off-white | | 安定性： | Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months. | | InChI | InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H | | InChIKey | MJPARFLICDXWJT-UHFFFAOYSA-N | | SMILES | C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl | | CAS データベース | 111974-74-4(CAS DataBase Reference) |
| | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Usage And Synthesis |
| 説明 | Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4 | | 化学的特性 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid | | 使用 | 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic | | 使用 | N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic. | | 参考文献 | 1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213
2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102
3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209
4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709 |
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