盐酸艾替伏辛
| 中文名称 | 盐酸艾替伏辛 |
|---|---|
| 中文同义词 | 盐酸艾替伏辛;艾替伏辛盐酸盐;盐酸依替福辛 |
| 英文名称 | 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride |
| 英文同义词 | 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine monohydrochloride;Etifoxine·hydrochloride;6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-aminehydrochloride;2-EthylaMino-6-chloro-4-Methyl-4-phenyl-4H-3,1-benzoxazine Hydrochloride;6-Chloro-N-ethyl-4-Methyl-4-phenyl-4H-3,1-benzoxazin-2-aMine Hydrochloride;StresaM;6-Chloro-2-(ethylamino)-4-methyl-4-phenyl-4H-3,1-benzoxazine hydrochloride;HOE-36801 hydrochloride |
| CAS号 | 56776-32-0 |
| 分子式 | C17H18Cl2N2O |
| 分子量 | 337.24362 |
| EINECS号 | 260-380-0 |
| 相关类别 | Amines;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;API |
| Mol文件 | 56776-32-0.mol |
| 结构式 |  |
盐酸艾替伏辛 性质
| 熔点 | ND |
|---|---|
| 储存条件 | -20°C |
| 溶解度 | 二甲基亚砜：≥5mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米色 |
| 稳定性 | 吸湿性 |
Etifoxine hydrochloride是一个非苯二氮卓类的、具有 GABA 能的化合物，是 GABAA 受体亚基 α1β2γ2 和 α1β3γ2 的阳性变构调节剂。Etifoxine hydrochloride 在啮齿类动物中显示出抗焦虑和抗惊厥活性。
Etifoxine (EFX), at concentrations ranging from 10 to 300 μM (higher concentrations limited its solubility), produces a dose-dependent increase in the [3H]muscimol binding at equilibrium, to 155±2% of its control value at 300 μM EFX.
Etifoxine competitively inhibits [
35
S]TBPS binding with micromolar potency in rat brain.
Etifoxine (3.125-50 mg/kg) exhibits more pronounced anxiolytic and anticonvulsant effects in the BALB/cByJ mice compared to the C57BL/6J mice.
| Animal Model: | Six-week old BALB/cByJ and C57BL/6J mice (20-25 g). |
| Dosage: | 3.125-50 mg/kg. |
| Administration: | Intraperitoneal inhection. |
| Result: |
Significantly increased the amount of time spent on the open arms at the 12.5 mg/kg dose when compared to vehicle (p = 0.009) in BALB/cByJ mice but produced no effect in C57B/6J mice.
BALB/cByJ mice compared with C57BL/6J mice exhibited significantly (p < 0.012) lower plasma levels of the compound at 15 and 30 min. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-16579 | 盐酸艾替伏辛 Etifoxine hydrochloride | 56776-32-0 | 5mg | 700元 |
| 2024/04/30 | HY-16579 | 盐酸艾替伏辛 Etifoxine hydrochloride | 56776-32-0 | 50mg | 2800元 |