fluazacort

fluazacort Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Fluazacort;L 6400;L6400;L-6400;Fluazacortum
CAS:19888-56-3
Package:10 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:Fluazacort
CAS:19888-56-3
Purity:NLT 98% Remarks:MC537265
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:Fluazacort
CAS:19888-56-3
Package:100Mg,10Mg
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:Fluazacort;(11β,16β)-21-(Acetyloxy)-9-fluoro-11-hydroxy-2'-Methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione; Azacortid; L 6400; 9α-Fluoro-11β,21-dihydroxy-3,20-dioxo-1,4-pregnadieno[17α,16α-d]-2-Methyloxazoline 21-Acetate;
CAS:19888-56-3
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Tel: +86-400-002-6226
Email: sales@rrkchem.com
Products Intro: Product Name:Fluazacort
CAS:19888-56-3
fluazacort Basic information
Product Name:fluazacort
Synonyms:(16β)-21-(Acetoxy)-9-fluoro-11β-hydroxy-2'-methylpregnano[17,16-d]oxazole-1,4-diene-3,20-dione;(5'β)-9-Fluoro-11β,21-dihydroxy-2'-methylpregnano[17,16-d]oxazole-1,4-diene-3,20-dione 21-acetate;Azacortid;L-6400;fluazacort;(11β,16β)-21-(Acetyloxy)-9-fluoro-11-hydroxy-2'-Methyl-5'H-pregna-1,4-dieno[17,16-d]oxazole-3,20-dione;9α-Fluoro-11β,21-dihydroxy-3,20-dioxo-1,4-pregnadieno[17α,16α-d]-2-Methyloxazoline 21-Acetate;Fluazacortum
CAS:19888-56-3
MF:C25H30FNO6
MW:459.51
EINECS:243-400-2
Product Categories:Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:19888-56-3.mol
fluazacort Structure
fluazacort Chemical Properties
Melting point 252-255°
alpha D +54.8° (c = 0.5 in CHCl3)
Safety Information
MSDS Information
fluazacort Usage And Synthesis
OriginatorAzacortid,Richter,Italy,1975
Usesfluazacort is a glucucorticoid with anti-inflammatory properties used in the treatment of skin diseases.
DefinitionChEBI: Fluazacort is a corticosteroid hormone.
Manufacturing ProcessTo a solution of 2.4 g of pregna-1,4,9(11)-triene-21-ol-3,20-dione-[17α,16α- d]-2'-methyloxazoline 21-acetate in 24 ml of tetrahydrofuran, 12.8 ml of 0.46 N perchloric acid are added at 15°C under stirring. N-bromoacetamide (1.1 g) is then added to the mixture which is kept far from light, and stirred for 4 hours at room temperature. After lowering the temperature to 10°C, a saturated solution of sodium bisulfite is added in order to decolorize the mixture, which is then poured into 120 ml of ice water. A product separates, which is collected by filtration, washed with water and then dried, thus obtaining 2.81 g of crude 9α-bromo-pregna-1,4-diene-11β,21-diol-3,20-dione- [17α,16α-d]-2'-methyloxazoline-21-acetate (yield 93%), MP 175°C to 176°C. An amount of 2.75 g of 9α-brorno-pregna-1,4-diene-11β,21-diol-3,20-dione- [17α,16α-d]-2'-methyloxazoline-21-acetate is dissolved under nitrogen in 137 ml of a mixture methanol:chloroform (3:2). The solution is put in ice bath and 5.5 ml of 1 N NaOH are then added within 10 minutes followed by 5.5 ml within the next 40 minutes. A strong stirring is provided for 2 hours and the temperature is kept between 0°C and 5°C, then the pH is adjusted to 7 to 8 with glacial acetic acid. The solvent is evaporated in vacuo to 20 ml of volume of solution, that is poured into ice water (130 ml). The product is collected by filtration, washed with water and dried. Yield: 1.6 g (80%), MP 221°C to 222°C. It is pregna-1,4-diene-9β,11β-epoxy-21-ol-3,20-dione-[17α,16α-d]-2'- methyloxazoline.
An amount of 1 g of the above product is dissolved in 9.4 ml of a mixture obtained by mixing 4.67 ml of hydrofluoric acid with 8.5 ml of tetrahydrofuran at the temperature of 0°C. This solution is stirred for 20 hours at the same temperature, then under strong stirring and cooling 20 ml of tetrahydrofuran are added. The solution is subsequently neutralized by the addition of 24 g of sodium bicarbonate followed by 1 g of sodium sulfate. The inorganic substance is collected and washed with ethyl acetate. The filtrate is evaporated to dryness and the product is crystallized from acetone: 0.65 g (yield 61%) of pregna-1,4-dien-9α-fluoro-11β,21-diol-3,20-dione-[17α,16α-d]- 2'-methyloxazoline are obtained, MP 241°C to 244°C [α]D = +83.5 (c. 0.5, CHCl3).The 21-acetate has MP 252°C to 255°C [α]D = +54.8 (c. 0.5, CHCl3).
Therapeutic FunctionAntiinflammatory
fluazacort Preparation Products And Raw materials
Raw materialsSodium hydroxide-->N-BROMOACETAMIDE-->Hydrogen fluoride-->hydrogen fluoride
Tag:fluazacort(19888-56-3) Related Product Information
2,4,4-TRIMETHYL-2-OXAZOLINE 2-HEXANONE, 3-AMINO-5-METHYL- 1-AMINOOCTAHYDRO-1H-INDEN-2-OL N-BOC-L-CYCLOHEXYLGLYCINOL (4R)-4-T-BUTYL-2-METHYL 2-OXAZOLINE 4,4-DIMETHYL-2-OXAZOLINE fluazacort