| Company Name: |
Wuhan Yanzhe Technology Co., Ltd
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| Tel: |
15527250409 |
| Email: |
wenhaotian12@163.com |
| Products Intro: |
Product Name:Colestipol HCl
CAS:26658-42-4
Purity:98% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;76g;
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| Company Name: |
Pharma Affiliates
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| Tel: |
172-5066494 |
| Email: |
@pharmaffiliates.com |
| Products Intro: |
Product Name:Colestipol HCl
CAS:26658-42-4
|
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| | Colestipol HCl Basic information |
| Product Name: | Colestipol HCl | | Synonyms: | tetraethylenepentamine/ epichlorohydrin copolymer;1,2-Ethanediamine, N-(2-aminoethyl)-N'-[2-[( 2-aminoethyl)amino]ethyl]-, polymer with (chloromethyl)oxirane | | CAS: | 26658-42-4 | | MF: | C11H28ClN5O | | MW: | 281.83 | | EINECS: | | | Product Categories: | Polymers | | Mol File: | 26658-42-4.mol |  |
| | Colestipol HCl Chemical Properties |
| | Colestipol HCl Usage And Synthesis |
| Originator | Colestid,Upjohn,US,1977 | | Uses | Antihyperlipidemic. | | Manufacturing Process | Into a 1,000 gallon, jacketed, glass-lined reactor equipped with baffles and a
two-speed (67 and 135 rpm) reversed impeller is introduced 200 g of
Richonate 60B (a 60% aqueous slurry of sodium salts of alkylbenzenesulfonic
acids) and 364 liters of deionized water, followed by 90.5 kg of
tetraethylenepentamine rinsed in with 5 gallons of toluene. The solution is
stirred at the low speed and then 500 gallons of toluene are added to form a
dispersion. To the stirred dispersion is added 109 kg of epichlorohydrin, rinsed
in with 5 gallons of toluene, and the resulting mixture is heated at reflux for
two hours. The reaction mixture is cooled to about 20°C and then treated with
58.5 kg of a filtered 50% aqueous solution of sodium hydroxide. The mixture
is removed from the reactor and filtered, and the copolymer is collected and
dried by treating it first with hot (75°C to 80°C) filtered nitrogen and then
with an 80°C air stream. The resulting crude product is returned to the
reactor, washed extensively with filtered deionized water (at the low speed),
dried with an 80°C air stream and blended until homogeneous to give about
155 kg of a dry tetraethylenepentamine-epichlorohydrin copolymer
hydrochloride, particle diameter 0.002-0.02 inch. | | Brand name | Colestid (Pharmacia & Upjohn). | | Therapeutic Function | Antihyperlipoproteinemic |
| | Colestipol HCl Preparation Products And Raw materials |
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