Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][5-(4-fluorophenoxy)-4-methoxy-2-pyridinyl]- manufacturers
- TRPC6-IN-3
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2026-08-26
- CAS:2311863-36-0
- Purity: 99.93%
- Supply Ability: 10g
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| | Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][5-(4-fluorophenoxy)-4-methoxy-2-pyridinyl]- Basic information |
| | Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][5-(4-fluorophenoxy)-4-methoxy-2-pyridinyl]- Chemical Properties |
| Boiling point | 689.6±55.0 °C(Predicted) | | density | 1.325±0.06 g/cm3(Predicted) | | pka | 5.26±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][5-(4-fluorophenoxy)-4-methoxy-2-pyridinyl]- Usage And Synthesis |
| Uses | TRPC6-IN-3 (compound 17) is a potent, orally active transient receptor potential C6 ion channel (TRPC6) inhibitor. TRPC6-IN-3 modulates not only intracellular calcium concentration, but also membrane potential by modulating the flux of cations including calcium and sodium ions. TRPC6-IN-3 can be used in research of respiratory system[1]. | | in vivo | TRPC6-IN-3 (compound 17; 1-10 mg/kg; p.o.; orally 12 h and 2 h before LPS challenge; LPS-induced mice) inhibits LPS-induced vascular leakage and inhibits accumulation of Broncho-Alveolar-Lavage protein (BALF protein) in a mouse model[1].
TRPC6-IN-3 (3 mg/kg; p.o.; daily, for 4 d; H1N1-induced mice) reduces H1N1-induced vascular leakage in a mouse model[1]. | Animal Model: | LPS-induced mice[1] | | Dosage: | 1, 3, and 10 mg/kg | | Administration: | Oral administration; orally 12 h and 2 h before LPS challenge | | Result: | Reduced BALF protein concentration of 56 % at 3 mg/kg and 62 % at 10 mg/kg. |
| Animal Model: | H1N1-induced mice[1] | | Dosage: | 3 mg/kg | | Administration: | Oral administration; daily, for 4 days | | Result: | Inhibited Evans blue extravasation from the blood to the BALF and reduced BALF Evans blue by 24 % at 3 mg/kg. |
| | References | [1] Thierry B, et, al. Inhibitors of TRPC6 for treating respiratory conditions. WO2021209510. |
| | Methanone, [4-(6-amino-3-pyridazinyl)-1-piperidinyl][5-(4-fluorophenoxy)-4-methoxy-2-pyridinyl]- Preparation Products And Raw materials |
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