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ChemicalBook Optimization Suppliers |
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| 主な危険性 | F,C | | Rフレーズ | 11-34 | | Sフレーズ | 16-26-36/37/39-45 | | RIDADR | UN 2924 3/PG 2 | | WGK Germany | 3 | | RTECS 番号 | GZ1005000 | | TSCA | Yes | | 国連危険物分類 | 3 | | 容器等級 | II | | HSコード | 29122990 |
| | シクロプロパンカルボキシアルデヒド Usage And Synthesis |
| 外観 | 無色～うすい黄色、液体 | | 使用上の注意 | 不活性ガス封入 | | 化学的特性 | clear colorless liquid | | 使用 | Cyclopropanecarboxaldehyde reacts with Grignard or organolithium reagents to give the expected secondary alcohols. These are susceptible to ring opening in the presence of HBr, providing stereoselective access to homoallylic bromides. It is also used in the synthesis of eta(2)-enonenickel complexes by reacting with [Ni(cod)(2)] (cod = 1,5-cyclooctadiene) and PBu(3) and to prepare a cyclopropylidene tetralone which underwent an enantioselective palladium-catalyzed [3+2] TMM cycloaddition providing a chiral spiro-fused cyclopentene. | | 定義 | ChEBI: Cyclopropanecarbaldehyde is an organooxygen compound. | | 主な応用 | Cyclopropanecarboxaldehyde is a reagent in the preparation of N-alkylphenylalaninamides of pyridinylphenyland oxobipyridinylamines as human GPR 142 agonists for potential use as anti-diabetic agents and the cytochrome P 450 inhibition. | | 製造方法 | Cyclopropanecarboxaldehyde is prepared by reaction of cyclopropylmethanol. The reaction needs reagent pyridinium chlorochromate and solvent CH2Cl2 with other condition of ambient temperature for 3 hours. The yield is about 60%. |
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