ASOXIME CHLORIDE
中文名称 | ASOXIME CHLORIDE |
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中文同义词 | 化合物 T14333;化合物ASOXIME DICHLORIDE |
英文名称 | ASOXIME CHLORIDE |
英文同义词 | HI 6 Chloride;1-[[[4-(Aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium chloride;4-Carbamoyl-1-[[[2-[(hydroxyimino)methyl]pyridinium-1-yl]methoxy]methyl]pyridinium dichloride;Transant;(((4-(iminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)pyridi;4’-carbamoyl-2-formyl-1,1’-(oxydimethylene)di-pyridinium-dichloride-2-oxime;hi6;hi-6 |
CAS号 | 34433-31-3 |
分子式 | C14H16Cl2N4O3 |
分子量 | 359.21 |
EINECS号 | |
相关类别 | Activators;Intermediates & Fine Chemicals;Pharmaceuticals;Amines;Heterocycles |
Mol文件 | 34433-31-3.mol |
结构式 |
ASOXIME CHLORIDE 性质
熔点 | 145-147°C |
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储存条件 | -20°C |
溶解度 | 在水中的溶解度为15mg/mL(澄清溶液) |
形态 | 粉末 |
颜色 | 白色至米色 |
稳定性 | 1-10%水溶液 |
Asoxime dichloride 是乙酰胆碱受体 (AChRs) 拮抗剂,包括烟碱受体,α7 乙酰胆碱受体。Asoxime dichloride 参与调节免疫应答。Asoxime dichloride 可作为抗原使用,改善神经系统的免疫效果。
IC50: acetylcholine receptors (AChRs)
Asoxime dichloride (intramuscular injection into the rear limb; 2% and 0.2% of median lethal dose 15.6 and 1.56 mg/kg; 21 or 65 days) significantly improved vaccination efficacy as a dose-dependent manner when KLH is 1 mg/kg. A combination of HI-6 and keyhole limpet hemocyanin (KLH) produces a vaccination of almost the same efficacy as that for Freund's complete adjuvant.
Animal Model: | Balb/c mice |
Dosage: | 2% and 0.2% of median lethal dose 15.6 and 1.56mg/kg |
Administration: | Intramuscular injection into the rear limb |
Result: | Improved vaccination efficacy at the level of immunity regulation by the nervous system. |
安全信息
WGK Germany | 3 |
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