| 公司名称： |
斯百全化学（上海）有限公司 |
| 联系电话： |
18616765336 |
| 产品介绍： |
英文名称:Quinacrine Hydrochloride, Dihydrate
CAS:6151-30-0
包装信息：25KGBL 备注：Q1013 |
| 公司名称： |
杭州杰恒化工有限公司 |
| 联系电话： |
0571-87396432 |
| 产品介绍： |
英文名称:Quinacrine,Atabrine Mepacnine
CAS:6151-30-0
|
| 公司名称： |
上海寰川实业有限公司 |
| 联系电话： |
021-61478794 |
| 产品介绍： |
英文名称:Mepacrine hydrochloride
CAS:6151-30-0
纯度：95% 包装信息：25g 100g |
| 公司名称： |
池州凯隆进出口贸易有限公司 |
| 联系电话： |
Please Email |
| 产品介绍： |
中文名称:米帕林盐酸盐; 奎纳克林盐酸盐; N4-(6-氯-2-甲氧基-9-吖啶基)-N1,N1-二乙基-1,4-戊二胺二盐酸盐二水合物
英文名称:1,4-PentanediaMine,N4-(6-chloro-2-Methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride, hydrate(1:2:2)
CAS:6151-30-0
纯度：Min 98% 包装信息：suitable for international transportation |
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| 中文名称: | 米帕林盐酸盐 | | 中文同义词: | N4-(6-氯-2-甲氧基-9-吖啶基)-N1,N1-二乙基-1,4-戊二胺二盐酸盐二水合物;奎纳克林盐酸盐;米帕林盐酸盐;盐酸阿伯平;米帕林;奎纳克林二盐酸盐二水合物 | | 英文名称: | Mepacrine hydrochloride | | 英文同义词: | QUINACRINE DIHYDROCHLORIDE DIHYDRATE;QUINACRINE HYDROCHLORIDE, DIHYDRATE;6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-acridindihydr;6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridinedihydroc;atabrinehydrochloridedihydrate;hloride2h2-o;mepacrinehcl;mepacrinehydrochloridedihydrate | | CAS号: | 6151-30-0 | | 分子式: | C23H36Cl3N3O3 | | 分子量: | 508.91 | | EINECS号: | | | 相关类别: | 医药原料药-科研原料;医药原料 | | Mol文件: | 6151-30-0.mol |  |
| 生物活性 | Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) 是一种抗疟剂 (antimalarial)，在体内外均具有抗肿瘤作用。Quinacrine hydrochloride hydrate 抑制 NF-κB 并激活 p53 信号转导，诱导肿瘤细胞发生凋亡 (apoptosis)。 | | 体外研究 |
Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .
Cell Viability Assay
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Cell Line:
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SGC-7901 cells
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Concentration:
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0, 5, 10, 15, and 20 μM
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Incubation Time:
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24 hours
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Result:
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Cell viability was inhibited in a dose-dependent manner, and the mean IC
50
value is 16.18 μM.
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Apoptosis Analysis
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Cell Line:
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SGC-7901 cells
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Concentration:
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7.5 and 15 μM
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Incubation Time:
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24 hours
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Result:
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The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%.
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Western Blot Analysis
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Cell Line:
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SGC-7901 cells
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Concentration:
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15 μM
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Incubation Time:
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24 hours
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Result:
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The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24.
The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19.
The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.
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| | 体内研究 |
Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.
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Animal Model:
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Female SCID mice with acute myeloid leukemia (AML)-PS model
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Dosage:
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100 mg/kg
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Administration:
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Administered by oral gavage (po); three times a week for two consecutive weeks
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Result:
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In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 | | 2021/06/02 | S5435 | 米帕林盐酸盐
Quinacrine Dihydrochloride Dihydrate | 6151-30-0 | 25mg | 794.67元 | | | 2021/03/30 | S5435 | 米帕林盐酸盐
Quinacrine Dihydrochloride Dihydrate | 6151-30-0 | 25mg | 794.67元 | |
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