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米帕林盐酸盐

米帕林盐酸盐 更多供应商
公司名称: 斯百全化学(上海)有限公司  
联系电话: 18616765336
产品介绍: 英文名称:Quinacrine Hydrochloride, Dihydrate
CAS:6151-30-0
包装信息:25KGBL 备注:Q1013
公司名称: 杭州杰恒化工有限公司  
联系电话: 0571-87396432
产品介绍: 英文名称:Quinacrine,Atabrine Mepacnine
CAS:6151-30-0
公司名称: 上海寰川实业有限公司  
联系电话: 021-61478794
产品介绍: 英文名称:Mepacrine hydrochloride
CAS:6151-30-0
纯度:95% 包装信息:25g 100g
公司名称: 池州凯隆进出口贸易有限公司  
联系电话: Please Email
产品介绍: 中文名称:米帕林盐酸盐; 奎纳克林盐酸盐; N4-(6-氯-2-甲氧基-9-吖啶基)-N1,N1-二乙基-1,4-戊二胺二盐酸盐二水合物
英文名称:1,4-PentanediaMine,N4-(6-chloro-2-Methoxy-9-acridinyl)-N1,N1-diethyl-, hydrochloride, hydrate(1:2:2)
CAS:6151-30-0
纯度:Min 98% 包装信息:suitable for international transportation
公司名称: AN PharmaTech Co Ltd  
联系电话: 86(21)68097365
产品介绍: CAS:6151-30-0
最新发布供应信息
米帕林盐酸盐_广州贝尔卡生物科技有限公司
2021/10/25 9:08:38
米帕林盐酸盐_威尔曼医药集团有限公司
2021/10/25 8:21:13
米帕林盐酸盐
生物活性体外研究体内研究 MSDS 用途与合成方法 米帕林盐酸盐价格(试剂级) 上下游产品信息
中文名称:米帕林盐酸盐
中文同义词:N4-(6-氯-2-甲氧基-9-吖啶基)-N1,N1-二乙基-1,4-戊二胺二盐酸盐二水合物;奎纳克林盐酸盐;米帕林盐酸盐;盐酸阿伯平;米帕林;奎纳克林二盐酸盐二水合物
英文名称:Mepacrine hydrochloride
英文同义词:QUINACRINE DIHYDROCHLORIDE DIHYDRATE;QUINACRINE HYDROCHLORIDE, DIHYDRATE;6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-acridindihydr;6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridinedihydroc;atabrinehydrochloridedihydrate;hloride2h2-o;mepacrinehcl;mepacrinehydrochloridedihydrate
CAS号:6151-30-0
分子式:C23H36Cl3N3O3
分子量:508.91
EINECS号:
相关类别:医药原料药-科研原料;医药原料
Mol文件:6151-30-0.mol
米帕林盐酸盐
米帕林盐酸盐 性质
熔点 247 °C
水溶解性 2.8 g/100 mL
CAS 数据库6151-30-0(CAS DataBase Reference)
米帕林盐酸盐 用途与合成方法
生物活性Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) 是一种抗疟剂 (antimalarial),在体内外均具有抗肿瘤作用。Quinacrine hydrochloride hydrate 抑制 NF-κB 并激活 p53 信号转导,诱导肿瘤细胞发生凋亡 (apoptosis)。
体外研究

Quinacrine (5-20 μM; 24 hours) inhibits the growth of SGC-7901 cells.
Quinacrine (7.5 and 15 μM; 24 hours) induces apoptosis in SGC-7901 cells, which is associated with mitochondria-dependent signal pathway and involves p53 upregulation and caspase-3 activation pathway.
Quinacrine (15 μM; 24 hours) treatment significantly increased the levels of proapoptotic proteins, including cytochrome c, Bax, and p53, and decreased the levels of antiapoptotic protein Bcl-2, thus shifting the ratio of Bax/Bcl-2 in favor of apoptosis .

Cell Viability Assay

Cell Line: SGC-7901 cells
Concentration: 0, 5, 10, 15, and 20 μM
Incubation Time: 24 hours
Result: Cell viability was inhibited in a dose-dependent manner, and the mean IC 50 value is 16.18 μM.

Apoptosis Analysis

Cell Line: SGC-7901 cells
Concentration: 7.5 and 15 μM
Incubation Time: 24 hours
Result: The percentage of apoptotic cells, including the early phase and late phase apoptosis, increased to 26.30%, compared with control group of 3.37%.

Western Blot Analysis

Cell Line: SGC-7901 cells
Concentration: 15 μM
Incubation Time: 24 hours
Result: The relative quantity of cytochrome c protein was upregulated, increased from 0.10 to 0.24.
The relative quantity of p53 protein was dramatically increased, from 0.06 to 0.19.
The Bax/Bcl-2 ratio was dramatically elevated from 1.21 to 2.59.
体内研究

Quinacrine (100 mg/kg three times per week for two consecutive weeks) significantly suppresses circulating blast cells at days 30/31 and increases the median survival time (MST). Quinacrine does not decrease the body weight of treated animals at the tested dose.

Animal Model: Female SCID mice with acute myeloid leukemia (AML)-PS model
Dosage: 100 mg/kg
Administration: Administered by oral gavage (po); three times a week for two consecutive weeks
Result: In the first AML mouse in vivo study, evaluation of circulating leukemic cells detected in blood samples (in percent of white blood cells (WBC)) at day 30/31 showed 72% human tumor cells in the control mice, whereas in mice treated with Quinacrine, this was only 2.2%.
The MST of control mice was 34 days whereas it was 46 days in Quinacrine-treated mice.
安全信息
危险品标志 Xn
危险类别码 22-36/37/38
安全说明 26-37/39
MSDS信息
提供商语言
ACROS 英文
米帕林盐酸盐 价格(试剂级)
更新日期产品编号产品名称CAS编号包装价格
2021/06/02S5435米帕林盐酸盐
Quinacrine Dihydrochloride Dihydrate
6151-30-025mg794.67元
2021/03/30S5435米帕林盐酸盐
Quinacrine Dihydrochloride Dihydrate
6151-30-025mg794.67元
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