盐酸胺苯吖啶
中文名称 | 盐酸胺苯吖啶 |
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中文同义词 | 盐酸胺苯吖啶,安吖啶,胺苯吖啶,N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺;安吖啶盐酸盐;N-[4-(9-吖啶氨基)-3-甲氧苯基]甲基磺酰胺盐酸盐;盐酸胺苯吖啶;N-[4-(9-吖啶基氨基)-3-甲氧基苯基]甲基磺酰胺;安沙克林;胺苯丫啶;盐酸胺苯吖啶, ≥98% (HPLC) |
英文名称 | Amsacrine hydrochloride |
英文同义词 | m-AMSA, 4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride;Methanesulfone-m-anisidine-4'-[(9-acridinyl)amino] hydrochloride;Methanesulfon-m-anisidide 4'-(9-acridinylamino)-;Methansulfon-m-aniside, 4'-(9-acridinylamino)-, monohydrochloride;4-[9-ACRIDINYLAMINO]-N-[METHANE-SULFONYL]-M-ANISIDINE HYDROCHLORIDE;M-AMSA HYDROCHLORIDE;M-AMSA, HCL;Methanesulfonamide, N-4-(9-acridinylamino)-3-methoxyphenyl-, monohydrochloride |
CAS号 | 54301-15-4 |
分子式 | C21H20ClN3O3S |
分子量 | 429.92 |
EINECS号 | 637-255-8 |
相关类别 | 细胞信号和神经生物学;细胞生物学 |
Mol文件 | 54301-15-4.mol |
结构式 |
盐酸胺苯吖啶 性质
熔点 | 197-199 °C(lit.) |
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储存条件 | Refrigerator |
溶解度 | 加热和超声处理时在DMSO中的溶解度10 mg/mL |
形态 | 粉末 |
颜色 | 红色至棕色 |
Target | Value |
Topo II
() |
Amsacrine (mAMSA) blocks HERG currents in HEK 293 cells and Xenopus oocytes in a concentration-dependent manner, with IC 50 values of 209.4 nM and 2.0 μM, respectively. Amsacrine (mAMSA) causes a negative shift in the voltage dependence of both activation (−7.6 mV) and inactivation (−7.6 mV). HERG current block by Amsacrine (mAMSA) is not frequency dependent. In vitro studies of normal human lymphocytes with various concentrations of Amsacrine (mAMSA), show both increased levels of chromosomal aberrations, ranging from 8% to 100%, and increase SCEs, ranging from 1.5 times the normal at the lowest concentration studied (0.005 μg/mL) to 12 times the normal (0.25 μg/mL). Amsacrine (mAMSA)-induced apoptosis of U937 cells is characterized by caspase-9 and caspase-3 activation, increased intracellular Ca 2+ concentration, mitochondrial depolarization, and MCL1 down-regulation. Amsacrine induces MCL1 down-regulation by decreasing its stability. Further, amsacrine-treated U937 cells show AKT degradation and Ca 2+ -mediated ERK inactivation.
In animals treated with different doses of amsacrine (0.5-12 mg/kg), the frequencies of micronucleated polychromatic erythrocytes increase significantly after treatment with 9 and 12 mg/kg. Furthermore, the present study demonstrates for the first time that Amsacrine (mAMSA) has high incidences of clastogenicity and low incidences of aneugenicity whereas nocodazole has high incidences of aneugenicity and low incidences of clastogenicity during mitotic phases in vivo.
安全信息
危险品标志 | T |
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危险类别码 | 25-36/37/38 |
安全说明 | 26-45 |
危险品运输编号 | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS号 | PB1081000 |
海关编码 | 2933.99.8290 |
危险等级 | 6.1(b) |
包装类别 | III |
盐酸胺苯吖啶 化学药品说明书
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-13551A | Amsacrine hydrochloride | 5 mg | 360元 | |
2024/08/19 | HY-13551A | 盐酸胺苯吖啶 Amsacrine hydrochloride | 54301-15-4 | 10mM * 1mLin DMSO | 396元 |