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| 化学名: | 2,4-ジクロロベンジルアルコール | | 英語化学名: | 2,4-Dichlorobenzyl alcohol | | 别名: | 2,4-dichloro-benzylalcoho;benzylalcohol,2,4-dichloro-;myacidesp;2,4-DichlorobenzylAlcohol99%;Benzenemethanol, 2,4-dichloro-;2,4-DICHLOROBENZL ALCOHOL;30) 2,4-DICHLORO BENZYL ALCOHOL;Rapidosept | | CAS番号: | 1777-82-8 | | 分子式: | C7H6Cl2O | | 分子量: | 177.03 | | EINECS: | 217-210-5 | | カテゴリ情報: | Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Building Blocks;C7 to C8;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Benzhydrols, Benzyl & Special Alcohols;Alcohols;C7 to C8;Oxygen Compounds | | Mol File: | 1777-82-8.mol |  |
| 融点 | 55-58 °C(lit.) | | 沸点 | 150 °C (25 mmHg) | | 比重(密度) | 1.2970 (rough estimate) | | 蒸気圧 | 0.154Pa at 25℃ | | 屈折率 | 1.5756 (estimate) | | 闪点 | >230 °F | | 貯蔵温度 | 2-8°C | | 溶解性 | 1g/l | | 酸解離定数(Pka) | 13.60±0.10(Predicted) | | 色 | White to Off-White | | 水溶解度 | Soluble in water, methanol and chloroform. | | Merck | 14,3060 | | BRN | 1448652 | | InChIKey | DBHODFSFBXJZNY-UHFFFAOYSA-N | | LogP | 2.8 at 24℃ | | CAS データベース | 1777-82-8(CAS DataBase Reference) | | EPAの化学物質情報 | 2,4-Dichlorobenzenemethanol (1777-82-8) |
| 主な危険性 | Xi | | Rフレーズ | 36/37/38 | | Sフレーズ | 24/25 | | WGK Germany | 2 | | RTECS 番号 | DO0890000 | | Hazard Note | Irritant | | HSコード | 29062900 | | 毒性 | mouse,LD50,oral,2300mg/kg (2300mg/kg),Cosmetics and Toiletries. Vol. 95(6), Pg. 59, 1980. |
| | 2,4-ジクロロベンジルアルコール Usage And Synthesis |
| 外観 | 白色～微褐色の結晶または結晶性粉末 | | 用途 | 有機合成原料。 | | 化学的特性 | white to light yellow crystal powde | | 使用 | An surgical antiseptic. | | 使用 | 2,4-Dichlorobenzyl alcohol is an antiseptic found in commercially available throat lozenges. Also used deactivate Respiratory syncytial virus and SARS-Cov. | | 定義 | ChEBI: A member of the class of benzyl alcohols that is benzyl alcohol in which the hydrogens at positions 2 and 4 are replaced by chlorines. | | 一般的な説明 | 2,4-Dichlorobenzyl alcohol is a constituent of commercially available lozenges for acute sore throat caused by upper respiratory tract infections. | | 作用機序 | In-vitro evidence has demonstrated the virucidal effect of Amylmetacresol (AMC) and 2,4-dichlorobenzyl alcohol (DCBA) on a number of viruses associated with the common cold; a reduction in viral load is believed to have benefits in reducing the symptoms. The local anesthetic action of AMC/DCBA throat lozenges, a combination of the potent channel blocker – AMC and the reduced potency for sodium channel blockade DCBA – attenuate the effects of AMC, possibly as a result of competitive binding, which acts on a sodium channel blocker, and may be effective in relieving symptoms due to inflammation. Therefore, AMC/DCBA throat lozenge is thought to represent a useful option to meet patients' needs and avoid unnecessary prescription of antibiotics[1]. | | 臨床応用 | Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been marketed in many countries worldwide for pain relief in acute sore throat. Amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges have been shown to be safe and efficient in relieving of acute sore throat symptoms, and it produces an immediate symptomatic relief. Local symptomatic pain relief plays an important role in managing acute sore throat[1-2]. | | 副作用 | COMMON SIDE EFFECTS: Difficulty in breathing, Tongue soreness, Hypersensitivity reactions, Swelling of the face, Tongue, Throat and Neck. | | 参考文献 | [1] Ting W Tan. “Effectiveness of amylmetacresol and 2,4-dichlorobenzyl alcohol throat lozenges in patients with acute sore throat due to upper respiratory tract infection: a systematic review protocol.” JBI database of systematic reviews and implementation reports (2017): 862–872.
[2] Thomas, Michael J. “ACP Journal Club. Amylmetacresol and 2, 4-dichlorobenzyl alcohol lozenges were better than placebo lozenges for relief of acute sore throat.” Annals of Internal Medicine 153 4 (2010): JC2-6. |
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