|
ChemicalBook Optimization Suppliers |
|
| 化学名: | VDM11 | | 英語化学名: | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE | | 别名: | (5Z,8Z,11Z,14Z)-N-(4-HYDROXY-2-METHYLPHENYL)-5,8,11,14-EICOSATETRAENAMIDE;N-(4-HYDROXY-2-METHYLPHENYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;N-(4-HYDROXY-2-METHYLPHENYL)ARACHIDONYLAMIDE;N-ARACHIDONOYL-4-HYDROXY-2-METHYLANILIN;N-ARACHIDONYL-4-HYDROXY-2-METHYLANILIN;VDM 11;N-(4-Hydroxy-2-methylphenyl)arachidonylamide, (5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide;VDM 11 (in Tocrisolve(TM) 100) | | CAS番号: | 313998-81-1 | | 分子式: | C27H39NO2 | | 分子量: | 409.6 | | EINECS: | | | カテゴリ情報: | Cannabinoid receptor | | Mol File: | 313998-81-1.mol |  |
| 貯蔵温度 | −20°C | | 溶解性 | DMSO: >5 mg/mL, soluble | | 外見 | oil | | 色 | gold | | 安定性： | Light Sensitive |
| | VDM11 Usage And Synthesis |
| 説明 | Numerous analogs of arachidonoyl ethanolamide (AEA) potentiate its biological activity. This potentiation is ascribed either to inhibition of AEA reuptake into neurons, or inhibition of fatty amide acyl hydrolase (FAAH) within the neurons. VDM11 is an AEA transport inhibitor with essentially no activity on either the central cannabinoid receptor (CB1), peripheral cannabinoid receptor (CB2), or the vanilloid receptor 1 (VR1). However, VDM11 inhibits FAAH and monoacylglycerol lipase (MAGL) and may act as an alternative FAAH substrate. At a concentration of 3 μM, VDM11, like AM404, inhibits glutamergic synaptic transmission between hippocampal neurons. The mechanism of this effect may be a direct action on sodium channels. Thus, the use of anandamide analogs as uptake inhibitors and interpretation of the results must be undertaken with care. | | 使用 | VDM-11 is a selective inhibitor of the anandamide membrane transporter. | | 生物活性 | A potent and selective inhibitor of the anandamide membrane transporter (AMT), in water-soluble emulsion (for details see TocrisolveTM 100). IC 50 values for inhibition of AMT are 4-11 mM. Displays negligible agonist activity at the hVR1 receptor and very weak action at CB 1 and CB 2 receptors. K i values are > 5-10 mM at CB 1 and CB 2 . Active in vivo . Also available as pure oil dissolved in ethanol ((5Z,8Z,11Z,14Z)-N-(4-Hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide ). |
|