| 外観 | 無色～ほとんど無色透明液体 |
| 定義 | 本品は、次の化学式で表される脂肪族アルコールである。 |
| 用途 | トリートメント / コンディショナー,クレンジング,化粧水 / 乳液 / クリーム,ファンデーション / 下地,口紅 / グロス,アウトバスヘアケア,UVケア |
| 原料由来 | 液状高級脂肪酸/液状高級アルコール（植物系のみ） |
| 化粧品の成分用途 | エモリエント剤、香料 |
| 特徴 | ほぼ無色無臭で、植物由来の分枝鎖飽和アルコール。優れた加熱安定性。水添ポリイソブテンの使用感改良に優れた効果を発揮。 |
| 化学的特性 | Octyldodecanol occurs as a clear, colorless, or yellowish, oily liquid. |
| 化学的特性 | 2-Octyl-1-dodecanol is clear, colourless or yellowish, oily liquid. |
| 使用 | 2-Octyldodecane-1-ol have been used as a emulsion stabilizer for polymer matrix patches. |
| 使用 | 2-Octyl-1-dodecanol may be used to investigate its interaction with the hexameric capsules of resorcin[4]arene. It has been used as diluent in a extractant screening study for the recovery of putrescine (butylene-1,4-diamine, BDA) and cadaverine (pentylene-1,5-diamine, PDA) from aqueous solutions (fermentation broths) by liquid-liquid extraction. |
| 使用 | 2-Octyl-1-dodecanol have been used as a emulsion stabilizer for polymer matrix patches. |
| 調製方法 | 2-Octyl-1-dodecanol is produced by the condensation of two molecules of decyl alcohol. It also occurs naturally in small quantities in plants. |
| 一般的な説明 | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| 応用例（製薬） | Octyldodecanol is widely used in cosmetics and pharmaceutical
applications as an emulsifying and opacifying agent. It is primarily
used in topical applications because of its lubricating and emollient
properties.
Octyldodecanol has been used in the preparation of oil/water
microemulsions investigated as the vehicle for the dermal administration
of drugs having no or low skin penetration.Octyldodecanol
has also been evaluated as a solvent for naproxen when
applied topically.Studies of estimated permeability coefficient
suggest that octyldodecanol could be a potential dermal permeation
enhancer. |
| 安全性プロファイル | An eye and severe skin irritant.When heated to decomposition it emits acrid smoke andirritating vapors. |
| 安全性 | Octyldodecanol is widely used in cosmetics and topical pharmaceutical
formulations, and is generally regarded as nontoxic and
nonirritant at the levels employed as an excipient.
In acute oral toxicity studies in rats fed 5 g/kg of undiluted
octyldodecanol, no deaths were observed.In an acute dermal
toxicity study, intact and abraded skin sites of guinea pigs were
treated with 3 g/kg of undiluted octyldodecanol under occlusive
patches; no deaths occurred and no gross skin lesions were
observed.Octyldodecanol caused either no ocular irritation or
minimal, transient irritation in the eyes of rabbits.However, some
sources describe undiluted octyldodecanol as an eye and severe skin
irritant. |
| 貯蔵 | The bulk material should be stored in a well-closed container in a
cool, dry place, protected from light. In the original unopened
container, octyldodecanol can be stored for 2 years protected from
moisture at below 30°C. |
| 不和合性 | 2-Octyl-1-dodecanol is generally compatible with most materials encountered in cosmetic and pharmaceutical formulations. |
| 規制状況(Regulatory Status) | Included in the FDA Inactive Ingredients Database (topical,
transdermal, and vaginal preparations). Included in nonparenteral
medicines licensed in the UK. Included in the Canadian List of
Acceptable Non-medicinal Ingredients. |