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| 化学名: | ヒアルロン酸ナトリウム | | 英語化学名: | Sodium hyaluronate | | 别名: | cockscomb;Si-4402;Sl-1010;HYALURONIC ACID SODIUM FROM*STREPTOCOCCU S ZOOEPIDEM;HYALURONIC ACID SODIUM SALT F. STREPTO-C OCCUS EQUI SP.;HYALURONIC ACID SODIUM FROM ROOSTER*COMB;β-Sodium glucuronate-(1,3)-β-N-acetyl-D-glucosamine;Hyaluronic acid-Na-salt from rooster comb | | CAS番号: | 9067-32-7 | | 分子式: | C14H22NNaO11 | | 分子量: | 403.31 | | EINECS: | 618-620-0 | | カテゴリ情報: | Cosmetics;Substrates;API;9067-32-7 | | Mol File: | 9067-32-7.mol |  |
| 融点 | >209°C (dec.) | | 比旋光度 | D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951) | | 貯蔵温度 | -20°C | | 溶解性 | H2O: 5 mg/mL, clear, colorless | | 外見 | Powder | | 色 | White to cream | | PH | pH(2g/l,25℃) : 5.5～7.5 | | 水溶解度 | SOLUBLE | | Merck | 13,4776 | | 安定性： | Stable. Incompatible with strong oxidizing agents. | | InChIKey | MAKUBRYLFHZREJ-JWBQXVCJSA-M | | SMILES | [C@@H]1(O[C@H]2[C@H](O)[C@H]([C@H](O)O[C@@H]2C(=O)[O-])O)O[C@H](CO)[C@@H](O)C[C@H]1NC(=O)C.[Na+] |&1:0,2,3,5,6,9,15,18,21,r| | | LogP | -6.623 (est) | | CAS データベース | 9067-32-7(CAS DataBase Reference) |
| | ヒアルロン酸ナトリウム Usage And Synthesis |
| 外観 | 白色からうすい黄色、結晶性粉末～粉末又は顆粒 | | 定義 | 本品は、ヒアルロン酸(*)のナトリウム塩である。参照表示名称：ヒアルロン酸 | | 溶解性 | 水溶状：試験適合水に溶ける。 | | 化粧品の成分用途 | 皮膚コンディショニング剤 | | 化学的特性 | The PhEur 6.3 describes sodium hyaluronate as the sodium salt of
hyaluronic acid, a glycosaminoglycan consisting of D-glucuronic
acid and N-acetyl-D-glucosamine disaccharide units.
Sodium hyaluronate occurs as white to off-white powder or
granules. It is very hygroscopic. | | 使用 | sodium hyaluronate is used as a humectant to increase moisture in the skin, it may also serve as an emulsifier. Sodium hyaluronate is capable of binding 1,800 times its own weight in water. It is the sodium salt of hyaluronic acid and is the most commonly used form. | | 主な応用 | Sodium Hyaluronic is is an anionic, nonsulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. Sodium hyaluronate is widely used as follows:
antifungal agent.
prevents thromboembolic complications.
aldosterone antagonist used as an adjunct in the management of chronic heart failure.
suitable as substrate for hyaluronidase.
Surgical aid (ophthalmological). | | 定義 | Sodium Hyaluronate is a polysaccharide of linear and repeating structural units of the disaccharide D-glucuronic acid and N-acetylD-glucosamine. Hyaluronic acid in human body usually present as polymers with several million molecular weight, and the structural difference by the animal species has not been confirmed. | | 調製方法 | Sodium hyaluronate occurs naturally in vitreous humor, serum,
chicken combs, shark skin, and whale cartilage; it is usually
extracted and purified from chicken combs. It may also be
manufactured by fermentation of selected Streptococcus zooepidemicus
bacterial strains; sodium hyaluronate is removed from the
fermentation medium by filtration and purified by ultrafiltration. It
is then precipitated with an organic solvent and dried. | | brand name | Equron [Veterinary] (Fort
Dodge Animal Health); Legend (Bayer Animal Health);
Synacid [Veterinary] (Schering-Plough Animal Health). | | 応用例（製薬） | Sodium hyaluronate is the predominant form of hyaluronic acid at
physiological pH. The name hyaluronan is used when the
polysaccharide is mentioned in general terms, and in the literature
the terms hyaluronic acid and sodium hyaluronate are used
interchangeably.
Hyaluronan is used therapeutically to treat osteoarthritis in the
knee, and is an effective treatment for arthritic pain. Crosslinked
hyaluronan gels are used as drug delivery systems.
Hyaluronan is the most common negatively charged glycosaminoglycan
in the human vitreous humor, and is known to interact
with polymeric and liposomal DNA complexes, where hyaluronan
solutions have been shown to decrease the cellular uptake of
complexes.(4) This is useful for enhancing the availability and
retention time of drugs administered to the eye. It is immunoneutral,
which makes it useful for the attachment of biomaterials for use in
tissue engineering and drug delivery systems; it also has important
applications in the fields of vascosurgery and vascosupplementation. | | Biochem/physiol Actions | High molecular mass polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine which forms the core of complex proteoglycan aggregates found in extracellular matrix. | | 安全性 | Sodium hyaluronate is used in cosmetics and in topical, parenteral,
and ophthalmic pharmaceutical formulations. It is generally
regarded as a relatively nontoxic and nonirritant material. Sodium
hyaluronate has been reported to be an experimental teratogen.
LD50 (mouse, IP): 1.5 g/kg
LD50 (rabbit, IP): 1.82 g/kg
LD50 (rat, IP): 1.77 g/kg | | 貯蔵 | Sodium hyaluronate should be stored in a cool, dry place in tightly
sealed containers. The powder is stable for 3 years if stored in
unopened containers. | | 規制状況(Regulatory Status) | Included in the FDA Inactive Ingredients Database (topical gel
preparation). |
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