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Product Name:1-naphthyl 3,5-dinitrobenzoate
CAS:93261-39-3
Purity:98% Package:10mg;100mg;1g;10g;100g;1kg
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Shanghai EFE Biological Technology Co., Ltd.
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Product Name:napthalen-1-yl 3,5-dinitrobenzoate
CAS:93261-39-3
Purity:98% Package:1mg;5mg;10mg
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Product Name:1-Naphthyl 3,5-dinitrobenzoate
CAS:93261-39-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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Product Name:1-naphthyl 3,5-dinitrobenzoate
CAS:93261-39-3
Purity:98% Package:25mg; 5mg; 10mg Remarks:Medbio
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| | 1-naphthyl 3,5-dinitrobenzoate Basic information |
| Product Name: | 1-naphthyl 3,5-dinitrobenzoate | | Synonyms: | 1-naphthyl 3,5-dinitrobenzoate;1-(3,5-DINITROBENZOATE) 1-NAPHTHALENOL;napthalen-1-yl 3,5-dinitrobenzoate;JMC-4;naphthalen-1-yl 3,5-dinitrobenzoate;1Naphthyl 3,5dinitrobenzoate,1 Naphthyl 3,5 dinitrobenzoate;1-Naphthalenol, 1-(3,5-dinitrobenzoate) | | CAS: | 93261-39-3 | | MF: | C17H10N2O6 | | MW: | 338.27 | | EINECS: | | | Product Categories: | | | Mol File: | 93261-39-3.mol |  |
| | 1-naphthyl 3,5-dinitrobenzoate Chemical Properties |
| Melting point | 217-219 °C(Solv: toluene (108-88-3)) | | Boiling point | 541.4±40.0 °C(Predicted) | | density | 1.466±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | ≤0.1mg/ml in methanol;0.5mg/ml in DMSO | | form | crystalline solid |
| | 1-naphthyl 3,5-dinitrobenzoate Usage And Synthesis |
| Biological Activity | 1-naphthyl 3,5-dinitrobenzoate is a dual 5-lipoxygenase and microsomal prostaglandin e synthase-1 inhibitor.human 5-lipoxygenase (5-lox), a target for antiinflammation drug design, catalyzes the first two reactions in the production of leukotrienes from arachidonic acid (aa): oxygenation of aa to 5-hpete and further dehydration to leukotriene a4 (lta4). then lta4 is metabolized to other leukotrienes. furthermore, 5-lox is also found to play key roles in tumor formation and cancer metastasis and thus is considered as a potential target for anticancer drugs. | | in vitro | a previous study built a comparative model for the human 5-lox closed conformation and successfully used it in virtual screening. out of around 200 000 compounds, 105 compounds were selected for experimental test. in cell-free assay, 30 compounds were found to have ic50 values less than 100 μm and 11 with ic50 values less than 10 μm. eventually, 1-naphthyl 3,5-dinitrobenzoate was screened out to have inhibition activity in the human whole blood assay with ic50 values less than 10 μm. 1-naphthyl 3,5-dinitrobenzoate was also identified as efficient dualfunctional inhibitors of 5-lox and mpges-1 in both cell-free assay and cell-based assay. in addition, 1-naphthyl 3,5-dinitrobenzoate was able to simultaneously suppress the production of ltb4 and pge2 in human whole blood, and its targets was verified as 5-lox and mpges-1, not lta4h, cox-1, cox-2 [1]. | | IC 50 | 1 and 3.6 μm for 5-lipoxygenase and microsomal prostaglandin e synthase-1, respectively | | references | [1] wu, y. ,he, c.,gao, y., et al. dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors. journal of medicinal chemistry 55, 2597-2605 (2012). |
| | 1-naphthyl 3,5-dinitrobenzoate Preparation Products And Raw materials |
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