Zinterol hydrochloride
| 中文名称 | Zinterol hydrochloride |
|---|---|
| 中文同义词 | 化合物 T26350;盐酸津特罗;化合物 ZINTEROL HYDROCHLORIDE;N-(2-羟基-5-(1-羟基-2-((2-甲基-1-苯基丙-2-基)氨基)乙基)苯基)甲磺酰胺盐酸盐 |
| 英文名称 | Zinterol hydrochloride |
| 英文同义词 | MJ-9184-1;Zinterol hydrochloride;N-[5-[2-[(1,1-dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]-Methanesulfonamide Hydrochloride;Zinterol HCl;Zinterol hydrochloride >=98% (HPLC) |
| CAS号 | 38241-28-0 |
| 分子式 | C19H27ClN2O4S |
| 分子量 | 414.94668 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 38241-28-0.mol |
| 结构式 |  |
Zinterol hydrochloride 性质
| 储存条件 | room temp |
|---|---|
| 溶解度 | 在DMSO中的溶解度≥15mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| InChI | 1S/C19H26N2O4S/c1-19(2,12-14-7-5-4-6-8-14)20-13-18(23)15-9-10-17(22)16(11-15)21-26(3,24)25/h4-11,18,20-23H,12-13H2,1-3H3 |
| InChIKey | XJBCFFLVLOPYBV-UHFFFAOYSA-N |
| SMILES | CC(C)(Cc1ccccc1)NCC(O)c2ccc(O)c(NS(C)(=O)=O)c2 |
Zinterol hydrochloride (MJ 9184 hydrochloride) 是一种有效的选择性 β2-肾上腺素受体 (β2-adrenoceptor) 激动剂。Zinterol hydrochloride 增强 ICa，EC50 为 2.2 nM。Zinterol hydrochloride 诱发清醒心力衰竭家兔室性心律失常。
β2-adrenoceptor
Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits.
| Animal Model: | In New Zealand White HF rabbits of either sex |
| Dosage: | 1.0 or 2.5 μg/kg |
| Administration: | Intravenous bolus administration; over 5 seconds |
| Result: |
2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/09/15 | HY-14304A | Zinterol hydrochloride Zinterol hydrochloride | 38241-28-0 | 1mg | 1550元 |
| 2026/09/15 | HY-14304A | Zinterol hydrochloride Zinterol hydrochloride | 38241-28-0 | 5mg | 2500元 |