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N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE

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N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Suppliers list
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Corrector C4
CAS:421580-53-2
Purity:98.64% Package:1mg;195USD|5mg;483USD|10mg;692USD
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Corrector C4；Corr4a;Corr 4a;Corrector C 4;Corr-4a;Corrector C-4
CAS:421580-53-2
Package:10 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
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Products Intro: Product Name:N-5-2-(5-Chloro-2-methoxy-anilino)thiazol-4-yl-4-methyl-thiazol-2-ylbenzamide
CAS:421580-53-2
Purity:95%HPLC Package:500mg;1g;5g;10g
Company Name: NANJING TOMMLAB PHARMATECH Co.,LTD  
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Products Intro: Product Name:421580-53-2
CAS:421580-53-2
Purity:>=95% Package:100mg;500mg;1g;5g;10g;50g
Company Name: TargetMol Chemicals Inc.  
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Products Intro: Product Name:Corrector C4
CAS:421580-53-2
Purity:98.64% Package:1mg/RMB 1300;5mg/RMB 3250;10mg/RMB 4750

N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE manufacturers

  • Corrector C4
  • Corrector C4 pictures
  • $195.00 / 1mg
  • 2025-11-10
  • CAS:421580-53-2
  • Min. Order:
  • Purity: 98.36%
  • Supply Ability: 10g
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Basic information
Product Name:N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
Synonyms:N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE;N-[2-(5-CHLORO-2-METHOXY-PHENYLAMINO)-4'-METHYL-[4,5']BITHIAZOLYL-2'-YL]-BENZAMIDE;N-[5-[2-(5-Chloro-2-methoxy-anilino)thiazol-4-yl]-4-methyl-thiazol-2-yl]benzamide;N-[5-[2-(5-chloro-2-methoxyanilino)-1,3-thiazol-4-yl]-4-methyl-1,3-thiazol-2-yl]benzamide;Corrector C4;Benzamide, N-[2-[(5-chloro-2-methoxyphenyl)amino]-4'-methyl[4,5'-bithiazol]-2'-yl]-;CFTR-F508del Corrector II, Corr-4a
CAS:421580-53-2
MF:C21H17ClN4O2S2
MW:456.97
EINECS:
Product Categories:
Mol File:421580-53-2.mol
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Structure
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Chemical Properties
density 1.440±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 100mg/mL
pka6.81±0.70(Predicted)
form solid
color light beige
Safety Information
MSDS Information
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Usage And Synthesis
UsesCorr4A is a chemical corrector, which can be used for cystic fibrosis. Corr4A interacts directly with the cystic fibrosis transmembrane conductance regulator (CFTR) or affects indirectly its folding process. Corr4A increases the expression of CFTR ΔF508 on the cell surface, thereby improving its transport to the plasma membrane and increasing the stability of the rescued mutant protein[1].
General DescriptionA cell-permeable bisaminomethylbithiazole compound that is reported to rescue/correct the folding defect of CFTR ΔF508 mutant via direct interaction and promote proper trafficking/glycosylation and surface expression in both transfected cells and primary airway epithelial cells from ΔF508-homozygous patients, while exhibiting little correcting effect toward N1303K-CFTR, P574H-CFTR, M345T-DRD4 (dopamine receptor 4), or G268V-ABCA1/CD243 /MDR1/ P-gp mutant. Reported to enhance the folding efficiency of both ΔF508 (by 3-fold at 10μM in FRT cells) and wild-type CFTR (by up to 70%), delay the ER-associated degradation of the core-glycosylated ΔF508 (by 30% at 10μM in FRT cells), and increase the stability of low-temperature resuced ΔF508 mutant on the plasma membrane (by 1.7-fold at 10μM in FRT cells). Corr-4a is shown to be more effective than VRT-325/CFcor-325 n restoring forskolin-stimulated CFTR activity in FRT and A549 ΔF508-CFTR transfectants. Unlike VRT-532 Corr-4a does not affect mutant CFTR channel gating activity.
References[1] Grove DE, et al., Mechanisms for rescue of correctable folding defects in CFTRDelta F508. Mol Biol Cell. 2009 Sep;20(18):4059-69. DOI:10.1091/mbc.e08-09-0929
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE Preparation Products And Raw materials
Tag:N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE(421580-53-2) Related Product Information
N-(2-[(5-CHLORO-2-METHOXYPHENYL)AMINO]-4'-METHYL-4,5'-BI-1,3-THIAZOL-2'-YL)BENZAMIDE
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