Ozanimod

Ozanimod Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base)
CAS:1306760-87-1
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd
Tel: 010-60279497
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Ozanimod RPC1063
CAS:1306760-87-1
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Ozenoxacin
CAS:1306760-87-1
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:1306760-87-1
Purity:98% Package:g-Kg Remarks:White solid
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:1306760-87-1
Purity:0.99 Package:5MG;10MG;50MG;100MG,1G,5G

Lastest Price from Ozanimod manufacturers

  • Ozanimod
  • US $20.00 / KG
  • 2020-11-16
  • CAS:1306760-87-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1000KG
  • Ozanimod
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:1306760-87-1
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
Ozanimod Basic information
Product Name:Ozanimod
Synonyms:Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base);Ozanimod (RPC1063);Ozanimod;RPC1063;Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-;5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile;(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile;oxanimod(RPC1063)
CAS:1306760-87-1
MF:C23H24N4O3
MW:404.46
EINECS:814-246-9
Product Categories:
Mol File:1306760-87-1.mol
Ozanimod Structure
Ozanimod Chemical Properties
Boiling point 648.3±65.0 °C(Predicted)
density 1.30±0.1 g/cm3(Predicted)
pka14.73±0.10(Predicted)
Safety Information
MSDS Information
Ozanimod Usage And Synthesis
Enzyme inhibitorThis orally available S1PR1 modulator (FW = 404.46 g/mol; CAS 1306760- 87-1; Solubility: 81 mg/mL DMSO; < 1 mg/mL H2O), also named RPC1063 and 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden- 4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile, selectively targets sphingosine 1-Phosphate (S1P) receptors, which mediate multiple processes, including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Ozanimod is specific for S1P1R (IC50 = 0.4 nM) and S1P5R, inducing S1P1R internalization and reversibly reducing the number of circulating B and CCR7+ T lymphocytes in vivo. It shows high oral bioavailability and volume of distribution, and a circulatory half-life that supports once daily dosing. Oral ozanimod reduced inflammation and disease parameters in three autoimmune disease models, commending its use in the treatment of relapsing multiple sclerosis (RMS) and inflammatory bowel disease (IBD). Indeed, the safety and efficacy of this modulator ozanimod in relapsing multiple sclerosis is indicated on the basis of a randomized, placebo-controlled, Phase 2 trial. Other SIPR1-directed immunomodulators include laquinimod, ponesimod, and siponimod.
Ozanimod Preparation Products And Raw materials
Tag:Ozanimod(1306760-87-1) Related Product Information
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