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| | 6-ヒドロキシ-2,2-ジメチル-2H-ナフト[1,2-b]ピラン-5-カルボン酸メチル 製品概要 |
| 化学名: | 6-ヒドロキシ-2,2-ジメチル-2H-ナフト[1,2-b]ピラン-5-カルボン酸メチル | | 英語化学名: | MOLLUGIN | | 别名: | Rubimaillin;2H-Naphtho[1,2-b]pyran-5-carboxylic acid;6-hydroxy-2, 2-dimethyl-, methylester;2,2-Dimethyl-6-hydroxy-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester;6-Hydroxy-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5-carboxylic acid methyl ester;MOLLUGIN;Methyl 6-hydroxy-2,2-dimethylbenzo[h]chromene-5-carboxylate;RUBIMAILLIN; MOLLUGIN | | CAS番号: | 55481-88-4 | | 分子式: | C17H16O4 | | 分子量: | 284.31 | | EINECS: | 683-209-5 | | カテゴリ情報: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;reference substance | | Mol File: | 55481-88-4.mol | ![6-ヒドロキシ-2,2-ジメチル-2H-ナフト[1,2-b]ピラン-5-カルボン酸メチル](CAS/GIF/55481-88-4.gif) |
| | 6-ヒドロキシ-2,2-ジメチル-2H-ナフト[1,2-b]ピラン-5-カルボン酸メチル 物理性質 |
| 融点 | 132～134℃ | | 沸点 | 453.2±45.0 °C(Predicted) | | 比重(密度) | 1.239±0.06 g/cm3(Predicted) | | 貯蔵温度 | 2-8°C | | 溶解性 | Chloroform (Slightly), Ethyl Acetate (Slightly) | | 外見 | Solid | | 酸解離定数(Pka) | 8.40±0.40(Predicted) | | 色 | Yellow to Green |
| Sフレーズ | 24/25 | | HSコード | 29329990 |
| | 6-ヒドロキシ-2,2-ジメチル-2H-ナフト[1,2-b]ピラン-5-カルボン酸メチル Usage And Synthesis |
| 外観 | 白色～黄色～黄赤色粉末～結晶 | | 使用 | Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models. | | 定義 | ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols. |
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