| Company Name: |
Lynnchem
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029-85992781 17792393971 |
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info@lynnchem.com |
| Products Intro: |
Product Name:OLIGOMYCIN C
CAS:11052-72-5
Purity:>95% by HPLC Package:1mg;5mg |
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| | OLIGOMYCIN C Basic information |
| Product Name: | OLIGOMYCIN C | | Synonyms: | 12-Deoxyoligomycin A;Oligmycin C;OLIGOMYCIN C;OLIGOMYCIN C, STREPTOMYCES DIASTATOCHROMOGENES;Oligomycin A, 12-deoxy-;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,9,13-trione, 22-ethyl-3',4',5',6'-tetrahydro-7,11,15-trihydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'R,4E,5'S,6S,6'S,7R,8S,10R,11S,12S,14S,15S,16R,18E,20E,22R,25S,28S,29R)- | | CAS: | 11052-72-5 | | MF: | C45H74O10 | | MW: | 775.06 | | EINECS: | 234-276-0 | | Product Categories: | Antibiotics;Antibiotics A to;Antibiotics by Application;Antibiotics N-SAntibiotics;AntifungalAntibiotics;Antineoplastic and Immunosuppressive AntibioticsAntibiotics;Chemical Structure Class;Inhibits an EnzymeAntibiotics;Macrolides;Mechanism of Action;Spectrum of Activity | | Mol File: | 11052-72-5.mol |  |
| | OLIGOMYCIN C Chemical Properties |
| Boiling point | 876.2±65.0 °C(Predicted) | | density | 1.091 g/cm3 | | storage temp. | −20°C | | pka | 13.49±0.70(Predicted) | | form | White to off-white powder. | | Merck | 13,6902 |
| Hazard Codes | Xn | | Risk Statements | 22 | | RIDADR | 2811 | | RTECS | RK3335000 | | HazardClass | 6.1(b) | | PackingGroup | III | | Toxicity | LD50 ipr-mus: 8300 mg/kg JACSAT 80,6092,1958 |
| | OLIGOMYCIN C Usage And Synthesis |
| Description | Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin C is a minor component of the oligomycin complex (Item No. 11341) that acts as an inhibitor of the mitochondrial F1FO-ATP synthase.1 Inhibition of the ATP synthase by oligomycins leads to cell death.2 | | Uses | Oligomycin C is an ATP synthetase and RVD inhibitor. | | Uses | Oligomycin C, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. | | Safety Profile | A poison by intraperitoneal route.When heated to decomposition it emits acrid smoke andirritating vapors |
| | OLIGOMYCIN C Preparation Products And Raw materials |
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