CGP 20712 A
| 中文名称 | CGP 20712 A |
|---|---|
| 中文同义词 | 化合物 T10778 |
| 英文名称 | CGP 20712 A |
| 英文同义词 | CGP 20712A METHANESULFONATE SELECTIVE B1 ADRENOCE;1-(2-((3-Carbamoyl-4-hydroxy)phenoxy)ethylamino)-3-(4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy)-2-propanoldihyd;CGP207122HCl;CGP-20712A methanesulfonate salt;(±)-2-Hydroxy-5-[2-[[2-hydroxy-3-[4-[1-methyl-4-(trifluoromethyl)-1H-imidazol-2-yl]phenoxy]propyl] amino]ethoxy]-benzamide methanesulfonate salt;1-[2-((3-CARBAMOYL-4-HYDROXY)PHENOXY)ETHYLAMINO]-3-[4-(1-METHYL-4-TRIFLUOROMETHYL-2-IMIDAZOLYL)PHENOXY]-2-PROPANOL DIHYDROCHLORIDE;CGP 20712 DIHYDROCHLORIDE;CGP 20712 mesylate |
| CAS号 | 105737-62-0 |
| 分子式 | C24H29F3N4O8S |
| 分子量 | 590.57 |
| EINECS号 | |
| 相关类别 | Adrenoceptor |
| Mol文件 | 105737-62-0.mol |
| 结构式 |  |
CGP 20712 A 性质
| 储存条件 | 2-8°C |
|---|---|
| 溶解度 | 在水中的溶解度10 mg/mL |
| 形态 | 固体 |
| 颜色 | 白色 |
CGP 20712 A (CGP 20712 mesylate) 是一种高选择性 β1-adrenoceptor 拮抗剂，IC50 为 0.7 nM，是对 β2 肾上腺素受体的选择性约为 10,000 倍。
IC50: 0.7 nM (β1-adrenoceptor)
In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors.
Pretreatment of 8-day-old rats with 5 mg/kg CGP 20712 A do not change the plasma ACTH response to insulin injection.
安全信息
| WGK Germany | 3 |
|---|