| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:CGP 35348;(3-AMinopropyl)(diethoxyMethyl)phosphinicacid
CAS:123690-79-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Ascent Scientific
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| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
| Products Intro: |
Product Name:CGP 35348
CAS:123690-79-9
Package:10mg;50mg Remarks:GABAB antagonist, brain penetrant
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:CGP 35348
CAS:123690-79-9
Purity:>=97% (NMR) Package:5mg, 25mg Remarks:C5851
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| | CGP 35348 Basic information |
| Product Name: | CGP 35348 | | Synonyms: | CGP 35348;(3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID;(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate;CGP 35348 hydrate;P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid;Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-;spatial learning,neuromuscular,neonatal damage,CGP-35348,brain penetrant,GABA Receptor,CGP35348,Gamma-aminobutyric acid Receptor,centrally,GABAB,CGP 35348,Inhibitor,γ-Aminobutyric acid Receptor,inhibit,active;Phosphinic acid, P-(3-aminopropyl)-P-(diethoxymethyl)- | | CAS: | 123690-79-9 | | MF: | C8H20NO4P | | MW: | 225.22 | | EINECS: | | | Product Categories: | GABA/Glycine receptor;GABA | | Mol File: | 123690-79-9.mol |  |
| | CGP 35348 Chemical Properties |
| storage temp. | −20°C | | solubility | H2O: >10 mg/mL | | form | solid | | color | white | | Water Solubility | Soluble in water (100mM) |
| | CGP 35348 Usage And Synthesis |
| Uses | CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
- to study its effects on intrinsic optical signal (IOS) in rat hippocampus
- alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
- to study its effects on hepatocellular carcinoma cells (HCC)
| | Biological Activity | Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors. | | Biochem/physiol Actions | CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier. | | storage | Room temperature | | references | [1]. olpe hr, karlsson g, pozza mf, et al. cgp 35348: a centrally active blocker of gabab receptors. eur j pharmacol, 1990, 187(1): 27-38.
[2]. hammond dl, washington jd. antagonism of l-baclofen-induced antinociception by cgp 35348 in the spinal cord of the rat. eur j pharmacol, 1993, 234(2-3): 255-262.
[3]. hao jx, xu xj, wiesenfeld-hallin z. intrathecal gamma-aminobutyric acidb (gabab) receptor antagonist cgp 35348 induces hypersensitivity to mechanical stimuli in the rat. neurosci lett, 1994, 182(2): 299-302.
[4]. patel sm, ebenezer is. the effects of intraperitoneal and intracerebroventricular administration of the gabab receptor antagonist cgp 35348 on food intake in rats. eur j pharmacol, 2004, 503(1-3): 89-93. |
| | CGP 35348 Preparation Products And Raw materials |
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