| Company Name: |
BOC Sciences
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| Tel: |
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| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:DPPI 1c hydrochloride
CAS:866396-70-5
Purity:≥98% by HPLC Remarks:The hydrochloride salt form of DPPI 1c, which has been found to be an inhibitor of DPP-IV and could improve glucose tolerance in diabetic mice.
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:DPPI 1c hydrochloride
CAS:866396-70-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Nantong QuanYi Biotechnology Co., Ltd
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| Tel: |
0513-66337626 18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:DPPI 1c hydrochloride
CAS:866396-70-5
Purity:98%+ HPLC Package:10mg，500mg，1g，2g，5g，10g，More
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| | 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Basic information |
| | 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Chemical Properties |
| solubility | DMSO:31.28(Max Conc. mg/mL);100.0(Max Conc. mM)
Water:15.64(Max Conc. mg/mL);50.0(Max Conc. mM) | | form | A solid |
| | 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Usage And Synthesis |
| Description | DPPI 1c is an inhibitor of dipeptidyl peptidase 4. It decreased plasma glucose levels by 46 to 67% in an oral glucose challenge in fasted, diabetic KK/H1J mice when administered at doses ranging from 0.3 to 5 mg/kg. | | in vitro | 1-({[1-(Hydroxymethyl)cyclopentyl]amino}acetyl)pyrrolidine-2,5-cis-dicarbonitrile (1c) is an achiral, slow-binding (time-dependent) inhibitor of DPP-IV that is selective for DPP-IV over other DPP isozymes and proline specific serine proteases, and which has oral bioavailability in preclinical species and in vivo efficacy in animal models._x000D_
_x000D_
Reference: J Med Chem. 2006 Jun 1;49(11):3068-76. https://pubmed.ncbi.nlm.nih.gov/16722626/ | | in vivo | 1-({[1-(Hydroxymethyl)cyclopentyl]amino}acetyl)pyrrolidine-2,5-cis-dicarbonitrile (1c) is an achiral, slow-binding (time-dependent) inhibitor of DPP-IV that is selective for DPP-IV over other DPP isozymes and proline specific serine proteases, and which has oral bioavailability in preclinical species and in vivo efficacy in animal models._x000D_
_x000D_
Reference: J Med Chem. 2006 Jun 1;49(11):3068-76. https://pubmed.ncbi.nlm.nih.gov/16722626/ | | target | A DPP-4 inhibitor. | | storage | Desiccate at RT |
| | 1-[[[(1-Hydroxymethyl)cyclopentyl]amino]acetyl]-2,5-cis-pyrrolidinedicarbonitrile hydrochloride Preparation Products And Raw materials |
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